Effects of Growth Hormone Releasing Hormone Delivered by Plasmid Injection and Electroporation on the Immune Function and Body Condition Scores in Holstein Heifers

机译：质粒注射率释放激素释放激素对霍尔斯坦小母牛免疫功能和体内分数递送的生长激素释放激素

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Novel DNA-based technologies were recently introduced for various purposes, including to direct the in vivo production of hormones and other peptides for therapeutic or preventative applications. Growth hormone releasing hormone (GHRH) is a hypothalamic hormone with both direct and indirect effects on the maintenance of health and immune status under an array of conditions. Our previous studies have shown that delivery of optimized plasmids by intramuscular injection followed by electroporation is scalable and represents a promising approach for long-term stable production of GHRH in pigs and dogs. We have now tested this approach to optimize GHRH levels in Holstein heifers, and characterized the effects of the therapy on the imnlune and health status of the treated subjects and controls.

机译：最近出于各种目的引入了新型DNA的技术，包括指导体内产生激素和其他肽的治疗或预防性应用。生长激素释放激素（GHRH）是一种下丘脑，对在一系列条件下的健康和免疫状态的维持性直接和间接影响。我们以前的研究表明，通过肌内注射随后通过电穿孔输出优化的质粒是可扩展的，并且代表了猪和狗的长期稳定生产的有希望的方法。我们现在测试了这种方法来优化Holstein小母牛的GHRH水平，并表征治疗对治疗受试者和控制的滥用和健康状况的影响。

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《Annual Conference of American Association of Bovine Practitioners》|2005年||共1页
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Patricia A. Brown; William C. Davis; Ruxandra Draghia-Akli;
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1. Immune-enhancing effects of growth hormone-releasing hormone delivered by plasmid injection and electroporation. [J] . Brown PA, Davis WC, Draghia Akli R Molecular therapy: the journal of the American Society of Gene Therapy . 2004,第4期

机译：通过质粒注射和电穿孔递送的生长激素释放激素的免疫增强作用。
2. Injection of porcine growth hormone releasing hormone gene plasmid in skeletal muscle increases piglets' growth and whole body protein turnover [J] . Zhang Yong, Zhu Yu-Jing, Li Zhe, Livestock Science . 2008,第2a3期

机译：在骨骼肌中注射猪生长激素释放激素基因质粒可促进仔猪的生长和全身蛋白质更新
3. Effects of growth hormone-releasing factor and(or) thyrotropin-releasing hormone on growth, feed efficiency, carcass characteristics, and blood hormones and metabolites in beef heifers. [J] . Campbell?R M Journal of animal science . 1993,第9期

机译：生长激素释放因子和（或）促甲状腺激素释放激素对牛肉小母牛生长，饲料效率，car体特性以及血液激素和代谢产物的影响。
4. Effects of Growth Hormone Releasing Hormone Delivered by Plasmid Injection and Electroporation on the Immune Function and Body Condition Scores in Holstein Heifers [C] . Patricia A. Brown, William C. Davis, Ruxandra Draghia-Akli Annual Conference of American Association of Bovine Practitioners . 2005

机译：质粒注射率释放激素释放激素对霍尔斯坦小母牛免疫功能和体内分数递送的生长激素释放激素
5. Plasticity of pituitary hormone secretion, expression and cell numbers within the anterior pituitary glands of human growth hormone-releasing hormone transgenic mice: Focus on galanin, growth hormone, and prolactin. [D] . Moore, Joseph Patrick, Jr. 1997

机译：人类生长激素释放激素转基因小鼠的垂体前叶垂体激素分泌，表达和细胞数量的可塑性：专注于甘丙肽，生长激素和催乳激素。
6. Thyrotropin-Releasing Hormone (TRH) and Somatostatin (SST) but not Growth Hormone-Releasing Hormone (GHRH) nor Ghrelin (GHRL) Regulate Expression and Release of Immune Growth Hormone (GH) from Chicken Bursal B-Lymphocyte Cultures [O] . Santiago Pech-Pool, Laura C. Berumen, Carlos G. Martínez-Moreno, 2020

机译：促甲状腺激素释放激素（TRH）和生长抑素（SST）而不是生长激素释放激素（GHRH）或Ghrelin（GHRL）调节鸡法氏囊B淋巴细胞培养物中免疫生长激素（GH）的表达和释放
7. Thyrotropin-Releasing Hormone (TRH) and Somatostatin (SST), but not Growth Hormone-Releasing Hormone (GHRH) nor Ghrelin (GHRL), Regulate Expression and Release of Immune Growth Hormone (GH) from Chicken Bursal B-Lymphocyte Cultures [O] . Santiago Pech-Pool, Laura C. Berumen, Carlos G. Martínez-Moreno, 2020

机译：促甲状腺素 - 释放激素（TRH）和生长抑制素（SST），但不是生长激素释放激素（GHRH），NOR GHRELIN（GHRL），调节免疫生长激素（GH）的表达和释放来自鸡Bursal B淋巴细胞培养物

Effects of Growth Hormone Releasing Hormone Delivered by Plasmid Injection and Electroporation on the Immune Function and Body Condition Scores in Holstein Heifers

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