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首页> 外文期刊>Pediatric Pulmonology >Development and validation of a simple‐to‐use nomogram for predicting refractory Mycoplasma pneumoniae Mycoplasma pneumoniae pneumonia in children
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Development and validation of a simple‐to‐use nomogram for predicting refractory Mycoplasma pneumoniae Mycoplasma pneumoniae pneumonia in children

机译：用于预测难治性支原体肺炎支原体肺炎肺炎肺炎儿童肺炎的开发和验证

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摘要

Abstract Objective This study aimed to develop and validate a simple‐to‐use nomogram for predicting refractory Mycoplasma pneumoniae pneumonia (RMPP) in children. Methods A total of 73 children with RMPP and 146 children with general Mycoplasma pneumoniae pneumonia were included. Clinical, laboratory, and radiological data were obtained. A least absolute shrinkage and selection operator (LASSO) regression model was used to determine optimal predictors. The nomogram was plotted by multivariable logistic regression. The performance of the nomogram was assessed by calibration, discrimination, and clinical utility. Results The LASSO regression analysis identified lactate dehydrogenase, albumin, neutrophil ratio, and high fever as significant predictors of RMPP. This nomogram‐illustrated model showed good discrimination, calibration, and clinical value. The area under the receiver operating characteristic curve of the nomogram was 0.884 (95% CI, 0.823‐0.945) in the training set and 0.881 (95% CI, 0.807‐0.955) in the validating set. Calibration curve and Hosmer‐Lemeshow test showed good consistency between the predictions of the nomogram and the actual observations, and decision curve analysis showed that the nomogram was clinically useful. Conclusion A simple‐to‐use nomogram for predicting RMPP in early stage was developed and validated. This may help physicians recognize RMPP earlier.
机译：摘要目的这项研究旨在开发和验证一种简单使用的NOMOMONIAE肺炎肺炎（RMPP）在儿童中。方法还包括共有73名患有RMPP和146名含有一般支原体肺炎肺炎的儿童。获得临床，实验室和放射数据。最小的绝对收缩和选择运算符（套索）回归模型用于确定最佳预测因子。通过多变量的逻辑回归绘制了NOM图。通过校准，歧视和临床效用来评估NOM图的性能。结果套索回归分析鉴定乳酸脱氢酶，白蛋白，中性粒细胞比和高烧作为RMPP的重要预测因子。该载体图示的模型显示出良好的歧视，校准和临床价值。在验证套装中，ROMO图表的接收器操作特性曲线下的区域为0.884（95％CI，0.823-0.945），验证集中为0.881（95％CI，0.807-0.955）。校准曲线和Hosmer-Lemeshow测试显示了NOM图的预测和实际观测之间的良好一致性，决策曲线分析表明，NOM图临床上有用。结论开发并验证了一种用于预测RMPP的简单用途NOMPP。这可能有助于医生早些时候识别RMPP。

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  • 来源
    《Pediatric Pulmonology》 |2020年第4期|共7页
  • 作者

    Cheng Siying; Lin Jilei; Zheng Xuexiang; Yan Li; Zhang Yin; Zeng Qing; Tian Daiyin; Fu Zhou; Dai Jihong;

  • 作者单位

    Xiangya HospitalCentral South UniversityChangsha Hunan Province China;

    Department of Respiratory Disease Ministry of Education Key Laboratory of Child Development and;

    Department of Respiratory Disease Ministry of Education Key Laboratory of Child Development and;

    Department of Respiratory Disease Ministry of Education Key Laboratory of Child Development and;

    Department of Respiratory Disease Ministry of Education Key Laboratory of Child Development and;

    School of Public Health and ManagementChongqing Medical UniversityChongqing China;

    Department of Respiratory Disease Ministry of Education Key Laboratory of Child Development and;

    Department of Respiratory Disease Ministry of Education Key Laboratory of Child Development and;

    Department of Respiratory Disease Ministry of Education Key Laboratory of Child Development and;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 儿科学;
  • 关键词

    albumin; children; LDH; nomogram; RMPP;

    机译：白蛋白;儿童;LDH;ROMO图;RMPP;

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