...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies >Sedative and Analgesic Drug Rotation Protocol in Critically Ill Children With Prolonged Sedation: Evaluation of Implementation and Efficacy to Reduce Withdrawal Syndrome*
【24h】

Sedative and Analgesic Drug Rotation Protocol in Critically Ill Children With Prolonged Sedation: Evaluation of Implementation and Efficacy to Reduce Withdrawal Syndrome*

机译：延长镇静的镇静剂和镇痛药物旋转方案：减少戒断综合征的实施和功效评估*

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: The first aim of this study was to assess the implementation of a sedative and analgesic drug rotation protocol in a PICU. The second aim was to analyze the incidence of withdrawal syndrome, drug doses, and time of sedative or analgesic drug infusion in children after the implementation of the new protocol. Design: Prospective observational study. Setting: PICU of a tertiary care hospital between June 2012 and June 2016. Patients: All patients between 1 month and 16 years old admitted to the PICU who received continuous IV infusion of sedative or analgesic drugs for more than 4 days were included in the study. Interventions: A sedative and analgesic drug rotation protocol was designed. The level of sedation, analgesia, and withdrawal syndrome were monitored with validated scales. The relationship between compliance with the protocol and the incidence of withdrawal syndrome was studied. Measurements and Main Results: One-hundred pediatric patients were included in the study. The protocol was followed properly in 35% of patients. Sixty-seven percent of the overall cohort presented with withdrawal syndrome. There was a lower incidence rate of withdrawal syndrome (34.3% vs 84.6%; p < 0.001), shorter PICU length of stay (median 16 vs 25 d; p = 0.003), less time of opioid infusion (median 5 vs 7 d for fentanyl; p = 0.004), benzodiazepines (median 5 vs 9 d; p = 0.001), and propofol (median 4 vs 8 d; p = 0.001) in the cohort of children in which the protocol was followed correctly. Conclusions: Our results show that compliance with the drug rotation protocol in critically ill children requiring prolonged sedation may reduce the appearance of withdrawal syndrome without increasing the risk of adverse effects. Furthermore, it may reduce the time of continuous IV infusions for most sedative and analgesic drugs and the length of stay in PICU.
机译：目的：本研究的第一个目的是评估PICU中的镇静剂和镇痛药物旋转方案的实施。第二个目的是分析新议定书后儿童戒断综合征，药物剂量和镇痛药物输注的发病率。设计：前瞻性观察研究。环境：2012年6月至2016年6月之间的第三级护理医院PICU。患者：所有1个月和16岁的患者录取到接受镇静剂或镇痛药的连续IV输注超过4天的PICU被列入研究中。干预：设计了镇静剂和镇痛药旋转方案。监测镇静，镇痛和戒断综合征的水平被监测有验证的秤。研究了遵守协议与戒断综合征发生率之间的关系。测量和主要结果：一百个儿科患者纳入研究。在35％的患者中正确遵循该方案。六十七个整体队列呈现出戒断综合症。出现较低的戒断综合征发生率较低（34.3％vs 84.6％; p <0.001），较短的PICU逗留时间（中位数16 vs 25d; p = 0.003），较少的阿片类药物输注时间（中位5 vs 7 d芬太尼; p = 0.004），苯二氮卓卓（中值5 vs 9d; p = 0.001），以及正确遵循方案的儿童队列中的异丙酚（中值4 vs 8 d; p = 0.001）。结论：我们的研究结果表明，符合需要长期镇静的危重儿童的药物旋转方案可能会降低戒断综合征的外观，而不会增加不良反应的风险。此外，它可以减少最镇静和镇痛药的连续IV输注的时间和PICU的逗留时间。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号