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首页> 外文期刊>Pediatric diabetes. >Vitamin D level and gene polymorphisms in Korean children with type 1 diabetes
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Vitamin D level and gene polymorphisms in Korean children with type 1 diabetes

机译：韩国儿童的维生素D水平和基因多态性，患有1型糖尿病

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Abstract Background Vitamin D metabolism has been associated with type 1 diabetes. Objective We aimed to clarify the association of 25‐hydroxylase ( CYP2R1 ) and 1α‐hydroxylase ( CYP27B1 ) with risk of developing type 1 diabetes in Korean children. Methods In total, 252 children (96 type 1 diabetes and 156 healthy controls) under the age of 20 years were recruited. Serum 25‐hydroxyvitamin D (25OHD) and 1α,25‐dihydroxyvitamin D [1α,25(OH) 2 D] levels were determined. Allelic, genotypic, and haplotypic distribution of CYP2R1 (rs12794714, rs10766196, rs10741657, rs2060793, and rs10766197) and CYP27B1 (rs4646536, rs10877012, and rs3782130) polymorphisms were determined. Clinical and biochemical data were analyzed according to genotype. Results Mean vitamin D level was considerably lower, and vitamin D deficiency was more prevalent in children with type 1 diabetes than in healthy controls. The GG genotype of CYP2R1 rs12794714 and AA genotype of CYP2R1 rs10766196 were significantly associated with risk of developing type 1 diabetes (odds ratio 2.00, 95% confidence interval 1.176‐3.413 and odds ratio 1.88, 95% confidence interval 1.103‐3.195, respectively). The GG+GA genotype of CYP2R1 rs12794714 and AA+AG genotype of CYP2R1 rs10766196 were associated with prevalent vitamin D deficiency in children with type 1 diabetes. These genotypes did not differ with respect to glycosylated hemoglobin and daily insulin requirement. Conclusions Serum 25OHD and 1α,25(OH) 2 D levels were lower in children with type 1 diabetes than in healthy controls. CYP2R1 rs12794714 and rs10766196 polymorphisms were associated with a higher risk of type 1 diabetes. Thus, polymorphisms in vitamin D metabolism may contribute to susceptibility to type 1 diabetes in Korean children.
机译：摘要背景维生素D新陈代谢与1型糖尿病有关。目的我们旨在阐明25-羟化酶（CYP2R1）和1α-羟化酶（CYP27B1）的关联，风险在韩国儿童中发育1型糖尿病风险。招募了总共252名儿童（96型糖尿病和156型健康对照）的方法。测定血清25-羟基羟乙素D（25Ohd）和1α，25-二羟基维生素D [1α，25（OH）2d]水平。 CYP2R1的等位基因，基因型和单倍型分布（RS12794714，RS10766196，RS10741657，RS2060793和RS10766197）和CYP27B1（RS4646536，RS10877012和RS3782130）多态性。根据基因型分析临床和生化数据。结果平均维生素D水平相当较低，维生素D缺乏在1型糖尿病的儿童中比健康对照更普遍。 CYP2R1 rs12794714的GG基因型和CYP2R1 RS10766196的AA基因型与发育1型糖尿病的风险显着相关（差距2.00,95％置信区间1.176-3.413和赔率比为1.88,95％置信区间1.103-3.195）。 CYP2R1 RS12794714和CYP2R1 RS10766196的GG + GA基因型和AA + AG基因型与患有1型糖尿病患儿的普遍存在维生素D缺乏有关。这些基因型与糖基化血红蛋白和每日胰岛素要求不同。结论1型糖尿病儿童血清25Ohd和1α，25（OH）2d水平低于健康对照。 CYP2R1 RS12794714和RS10766196多态性与1型糖尿病的风险较高。因此，维生素D代谢中的多态性可能导致韩国儿童1型糖尿病的易感性。

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