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首页> 外文期刊>Pediatric diabetes. >The influence of body mass index and age on C‐peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial‐type 1
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The influence of body mass index and age on C‐peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial‐type 1

机译：参与糖尿病预防试验型1型儿童患儿1型糖尿病诊断的体重指数和年龄对C肽的影响

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Background/Objective The extent of influence of BMI and age on C‐peptide at the diagnosis of type 1 diabetes (T1D) is unknown. We thus studied the impact of body mass index Z‐scores (BMIZ) and age on C‐peptide measures at and soon after the diagnosis of T1D. Methods Data from Diabetes Prevention Trial‐Type 1 (DPT‐1) participants 18.0?years at diagnosis was analyzed. Analyses examined associations of C‐peptide measures with BMIZ and age in 2 cohorts: oral glucose tolerance tests (OGTTs) at diagnosis ( n ?=?99) and mixed meal tolerance tests (MMTTs) 6?months after diagnosis ( n ?=?80). Multivariable linear regression was utilized. Results Fasting and area under the curve (AUC) C‐peptide from OGTTs ( n ?=?99) at diagnosis and MMTTs ( n ?=?80) after diagnosis were positively associated with BMIZ and age ( P ??.001 for all). Associations persisted when BMIZ and age were included as independent variables in regression models ( P ??.001 for all). BMIZ and age explained 31%‐47% of the variance of C‐peptide measures. In an example, 2 individuals with identical AUC C‐peptide values had an approximate 5‐fold difference in values after adjustments for BMIZ and age. The association between fasting glucose and C‐peptide decreased markedly when fasting C‐peptide values were adjusted ( r ?=?0.30, P ??.01 to r ?=?0.07, n.s.). Conclusions C‐peptide measures are strongly and independently related to BMIZ and age at and soon after the diagnosis of T1D. Adjustments for BMIZ and age cause substantial changes in C‐peptide values, and impact the association between glycemia and C‐peptide. Such adjustments can improve assessments of β‐cell impairment at diagnosis.
机译：背景/目的BMI和年龄对1型糖尿病（T1D）诊断的C-肽的影响程度是未知的。因此，我们研究了T1D诊断后，在T1D诊断后立即对体重指数Z分数（BMIZ）和年龄的影响。方法糖尿病预防试验型（DPT-1）参与者的数据分析了诊断的诊断中的数据。分析诊断（n？=α99）和混合膳食耐受试验（n =Δ99）和混合膳食耐受试验（n =Δ99）和混合膳食耐受试验（n =Δ99）和混合膳食耐受试验（n =Δ99）和诊断后的混合膳食耐受试验（n？ =？80）。使用多变量线性回归。结果在诊断和mmtts（n？=Δ99）下的曲线（auc）c-肽的禁食和区域在诊断后（n？=Δ80）与bmiz和年龄呈正相关（p？001对所有人）。当BMIZ和年龄作为回归模型中的独立变量包含在BMIZ和年龄（P？001）时，关联持续存在。 BMIZ和年龄解释了C-肽措施方差的31％-47％。在一个例子中，具有相同的AUC C肽值的2个个体在对BMIZ和年龄的调整后具有近似的5倍差异。当调节禁食C肽值时，空腹葡萄糖和C-肽之间的关联显着降低（R？= 0.30，p≤01-r？= 0.07，N.S.）。结论C-肽措施与BMIZ和T1D诊断后不久的年龄密切相关。 BMIZ和年龄的调整导致C-肽值的大量变化，并影响糖血症和C肽之间的关联。这种调整可以改善诊断β细胞损伤的评估。

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