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首页> 外文期刊>Pediatric diabetes. >Remission phase in children diagnosed with type 1 diabetes in years 2012 to 2013 in Silesia, Poland: An observational study
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Remission phase in children diagnosed with type 1 diabetes in years 2012 to 2013 in Silesia, Poland: An observational study

机译：2012年至2013年诊断患有1型糖尿病患儿的儿童缓解阶段，波兰：一个观察研究

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Background/Objective The study aimed to analyze the frequency of partial remission (PR) and its association with chosen clinical and laboratory factors among pediatric patients with newly diagnosed type 1 diabetes (T1D). The long‐term effect of PR on chosen parameters was also investigated. Methods In 194 patients (95 girls) aged 8.1?±?4.3?years, we analyzed data at T1D onset: glycemia, pH, C‐peptide, antibodies, weight, and concomitant autoimmune diseases. Anthropometric parameters, daily insulin requirement (DIR), and HbA1c 2 and 4?years after T1D diagnosis were also analyzed. We determined PR based on HbA1c and DIR measurements at least every 3?months. Results PR occurred in 59% of patients. Remitters had significantly higher pH (7.33 vs 7.28, P ?=?0.03), weight SD score (SDS) (0.25 vs ?0.24, P ?=?0.002), and body mass index SDS (0.19 vs ?0.66, P ?=?0.02) compared with non‐remitters. Concomitant diseases correlated negatively with PR. Multivariate analysis indicated only pH at onset was an independent predictor of PR. pH was the most important factor associated with the beginning of PR. There was a positive correlation between the start and duration of PR. Four years after T1D onset remitters had lower HbA1c (7.24% vs 8.05%, 53 vs 63.9?mmol/mol, P ??0.001) and DIR (0.81 vs 1.08, P ?=?0.005). Conclusions PR occurred quite often and developed more frequently in children with higher: weight and BMI SDS, but the main factor influencing PR presence and duration was higher pH at T1D onset. There was a beneficial impact of PR on HbA1c and DIR after 4?years of treatment.
机译：背景/目的该研究旨在分析部分缓解（PR）的频率及其与新诊断的1型糖尿病（T1D）的儿科患者中所选择的临床和实验室因素的关系。还研究了PR对所选参数的长期效果。方法194例患者（95名女孩）8.1？±4.3？4.3岁，我们分析了T1D发作的数据：糖肿瘤，pH，C-肽，抗体，重量和伴随的自身免疫疾病。人类测量参数，每日胰岛素要求（DIR）和HBA1C 2和4？在T1D诊断后的几年内也分析。我们基于HBA1C和DIR测量至少每3个月确定PR。结果PR发生在59％的患者中。脱垫的pH值明显较高（7.33 Vs 7.28，p？= 0.03），重量SD得分（SDS）（0.25 Vs？0.24，P？= 0.002）和体重指数SDS（0.19 VS？0.66，P？=与非储料相比，0.02）。伴随的疾病与PR相关的负面相关。多变量分析表明了发病的pH是PR的独立预测因子。 pH是与PR开始相关的最重要因素。 Pr的开始和持续时间之间存在正相关。 T1D发作储层较低的HBA1C（7.24％Vs 8.05％，53 Vs 63.9？mmol / mol，p≤x≤0.0.8，0.0.81 Vs 1.08，p≤x≤0.005）。结论PR经常发生并在患有更高的儿童中更频繁地发展：重量和BMI SDS，但影响Pr存在和持续时间的主要因素在T1D发作时较高。 Pr对HBA1C和DIR有益的影响，在4年治疗后。

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