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Drug-Induced Urolithiasis in Pediatric Patients

机译：儿科患者的药物诱导尿道病

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摘要

Drug-induced nephrolithiasis is a rare condition in children. The involved drugs may be divided into two different categories according to the mechanism involved in calculi formation. The first one includes poorly soluble drugs that favor the crystallization and calculi formation. The second category includes drugs that enhance calculi formation through their metabolic effects. The diagnosis of these specific calculi depends on a detailed medical history, associated comorbidities and the patient's history of drug consumption. There are several risk factors associated with drug-induced stones, such as high dose of consumed drugs and long duration of treatment. Moreover, there are some specific risk factors, including urinary pH and the amount of fluid consumed by children. There are limited data regarding pediatric lithogenic drugs, and hence, our aim was to perform a comprehensive review of the literature to summarize these drugs and identify the possible mechanisms involved in calculi formation and discuss the management and preventive measures for these calculi.
机译：药物诱导的肾状性是儿童罕见的病情。根据结石形成的机制，所涉及的药物可以分为两种不同的类别。第一个包括有利于结晶和结石形成的可溶性药物。第二类包括通过代谢效应增强计算的药物。这些特定计算的诊断取决于详细的病史，相关的合并症和患者的药物消费史。有几种与药物诱导的石头相关的危险因素，如高剂量的消耗药物和长期治疗持续时间。此外，存在一些特定的风险因素，包括尿pH和儿童消耗的液体量。有限的数据有关儿科典型药物，因此，我们的目标是对文献进行全面审查，总结这些药物，并确定计算中参与的可能机制，并讨论这些计算的管理和预防措施。

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  • 来源
    《Pediatric drugs》 |2019年第5期|共22页
  • 作者

    Sighinolfi Maria Chiara; Eissa Ahmed; Bevilacqua Luigi; Zoeir Ahmed; Ciarlariello Silvia; Morini Elena; Puliatti Stefano; Durante Viviana; Ceccarelli Pier Luca; Micali Salvatore; Bianchi Giampaolo; Rocco Bernardo;

  • 作者单位

    Univ Modena &

    Reggio Emilia Dept Urol Via Pozzo 71 I-41100 Modena Italy;

    Univ Modena &

    Reggio Emilia Dept Urol Via Pozzo 71 I-41100 Modena Italy;

    Univ Modena &

    Reggio Emilia Dept Urol Via Pozzo 71 I-41100 Modena Italy;

    Univ Modena &

    Reggio Emilia Dept Urol Via Pozzo 71 I-41100 Modena Italy;

    Univ Modena &

    Reggio Emilia Dept Urol Via Pozzo 71 I-41100 Modena Italy;

    Univ Modena &

    Reggio Emilia Dept Urol Via Pozzo 71 I-41100 Modena Italy;

    Univ Modena &

    Reggio Emilia Dept Urol Via Pozzo 71 I-41100 Modena Italy;

    Univ Modena &

    Reggio Emilia Pediat Surg Dept Modena Italy;

    Univ Modena &

    Reggio Emilia Pediat Surg Dept Modena Italy;

    Univ Modena &

    Reggio Emilia Dept Urol Via Pozzo 71 I-41100 Modena Italy;

    Univ Modena &

    Reggio Emilia Dept Urol Via Pozzo 71 I-41100 Modena Italy;

    Univ Modena &

    Reggio Emilia Dept Urol Via Pozzo 71 I-41100 Modena Italy;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
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