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Efficacy and Safety of Ibuprofen in Infants Aged Between 3 and 6 Months

机译：布洛芬在3至6个月之间的婴儿中布洛芬的疗效和安全性

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摘要

Ibuprofen is a non-steroidal anti-inflammatory drug frequently administered to children of various ages for relief of fever and pain and is approved as an over-the-counter medication in many countries worldwide. Although there are extensive data on its efficacy and safety in children and adults, there are divergent dosing recommendations for analgesia and treatment of fever in infants, especially in the age group between 3 and 6 months of age. In this article, we have assessed the safety and efficacy of ibuprofen use in infants in an attempt to find the optimal method of pain and fever management in this specific age group. Based on the current evidence, short-term use of ibuprofen is considered safe in infants older than 3 months of age having a body weight above 5-6 kg when special attention is given to the hydration of the patient. Ibuprofen should be prescribed based on body weight using a dose of 5-10 mg/kg. This dose can be administered 3-4 times a day resulting in a maximum total daily dose of 30-40 mg/kg. The rectal route has been shown to be less reliable because of erratic absorption, especially in young infants. Since most efficacy and safety data have been derived from trials in infants with fever, future studies should focus on the efficacy of ibuprofen in young infants with pain.
机译：布洛芬是一种常规给予各种年龄儿童的非甾体类抗炎药，以缓解发烧和疼痛，并被批准为全球许多国家的逆下的药物。虽然儿童和成人的疗效和安全有广泛的数据，但患有镇痛和婴儿发烧的治疗有不同的给药推荐，特别是在3至6个月之间的年龄组。在本文中，我们评估了布洛芬在婴幼儿中使用的安全性和功效试图在该特定年龄组中找到最佳疼痛和发烧管理方法。基于目前的证据，在3个月龄超过3个月的婴幼儿的婴儿中被认为是安全的短期使用，当对患者的水合作合并时，患者体重超过5-6公斤。布洛芬应使用5-10mg / kg的剂量根据体重规定。该剂量可以每天3-4次施用，导致最大总每日剂量为30-40mg / kg。由于不稳定的吸收，特别是在年轻婴儿中，直肠路径被证明是不太可靠的。由于大多数疗效和安全数据来自发烧的婴儿试验，因此未来的研究应该专注于布洛芬在患有疼痛的年轻婴儿的疗效。

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  • 来源
    《Pediatric drugs》 |2017年第4期|共14页
  • 作者

    Ziesenitz Victoria C.; Zutter Andreas; Erb Thomas O.; van den Anker Johannes N.;

  • 作者单位

    Univ Basel Childrens Hosp Div Paediat Pharmacol &

    Pharmacometr Spitalstr 33 CH-4056 Basel;

    Univ Basel Div Paediat Anaesthesiol Childrens Hosp Basel Switzerland;

    Univ Basel Div Paediat Anaesthesiol Childrens Hosp Basel Switzerland;

    Univ Basel Childrens Hosp Div Paediat Pharmacol &

    Pharmacometr Spitalstr 33 CH-4056 Basel;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
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