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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Is Human Oxoguanine Glycosylase 1 Genetic Variant Successful Even on Oral Squamous Cell Carcinoma?
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Is Human Oxoguanine Glycosylase 1 Genetic Variant Successful Even on Oral Squamous Cell Carcinoma?

机译：甚至是口腔鳞状细胞癌的人氧杂蛋白糖基酶1遗传变异均成功吗？

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Background: Oral squamous cell carcinoma (OSCC) is one of the most widespread cancer types that arise from different sites of oral cavity and has a 5-year survival rate. This study is aimed at investigating the human oxoguanine glycosylase 1 (hOGG1)-Ser326Cys and APE-Asp148Glu polymorphisms of DNA repair genes in OSCC. Materials and Methods: We investigated the hOGG1-Ser326Cys and APE-Asp148Glu polymorphisms of DNA repair genes in the oral cavity. Genotyping was conducted using polymerase chain reaction-restriction fragment length polymorphism analysis based on 132 patients who were diagnosed as having OSCC and 160 healthy subjects. Results: Individuals with the genotype hOGG1-Ser326Cys, Cys allele carriers, were found significantly more frequently in the patient group compared to the control group as increase in risk (p < 0.001). Furthermore, it was observed that there were significantly more individuals with the Ser allele in the control group (p < 0.001). Individuals with genotype APE-Asp148Glu were not statistically significant; however, they were still more in the control group and provided protection against the disease. Conclusion: Our findings showed that hOGG1-Ser326Cys Cys allele is statistically important and relevant with respect to the development of oral squamous cancer. In view of our results, further studies including expression levels are required in which hOGG1-Ser326Cys should be investigated as molecular biomarkers for the early prediction of squamous cell carcinoma. (C) 2017 S. Karger AG, Basel
机译：背景：口腔鳞状细胞癌（OSCC）是来自口腔不同部位的最普遍癌症类型之一，并且存在5年的存活率。本研究旨在研究O​​SCC中的DNA修复基因的人氧杂体糖基酶1（HOGG1）-SER326CYS和APE-ASP148GLU多态性。材料和方法：我们研究了口腔中的DNA修复基因的Hogg1-Ser326cys和Ape-asp148glu多态性。基因分型使用聚合酶链反应限制片段长度多态性分析，基于诊断为具有OSCC和160个健康受试者的132名患者。结果：与对照组相比，患有Genotype Hogg1-Ser326cys，Cys等位基因携带者的患者群体的个体在患者群体中显着频繁地发现，因为对照组增加风险增加（P <0.001）。此外，观察到对照组中具有SER等位基因的个体显着增加（P <0.001）。具有基因型APE-ASP148GLU的个体在统计学上没有统计学意义;然而，他们还在对照组中仍然更多，并提供对疾病的保护。结论：我们的研究结果表明，Hogg1-Ser326cys Cys等位基因在统计上重要性和与口腔鳞癌的发展有统计重要性和相关性。鉴于我们的结果，需要进一步的研究，其中需要包括表达水平的进一步研究，其中应研究霍格1 -SER326CYS作为分子生物标志物，以便早期预测鳞状细胞癌。 （c）2017年S. Karger AG，巴塞尔

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