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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Liquid Biopsies for Monitoring Temporal Genomic Heterogeneity in Breast and Colon Cancers
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Liquid Biopsies for Monitoring Temporal Genomic Heterogeneity in Breast and Colon Cancers

机译：用于监测乳腺癌和结肠癌的颞基因组异质性的液体活组织检查

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摘要

Cancer is a spatial and temporal dynamic disease where differently evolving genetic clones are responsible for progression. In this landscape, the genomic heterogeneity of the primary tumours can be captured by deep-sequencing representative spatial samples. However, the recognition of genetic alterations responsible for tumour evolution remains a challenging task. Recently, the "liquid biopsy" was recognized as a powerful real-time approach for the molecular monitoring of this dynamic disease. The term "liquid biopsy" generally refers to the use of circulating (cell-free) tumour DNA (ctDNA) and circulating tumour cells (CTCs) as non-invasive biomarkers for the early diagnosis, prognosis, monitoring of clinical progression, and response to treatment in different types of tumours, including the highly genomic heterogeneous breast cancer. The implementation and standardization of both approaches are still needed to achieve the required sensitivity and specificity to successfully analyze heterogenous tumours, but pivotal studies, in particular those concerning colorectal cancer, have shown the feasibility and usefulness of liquid biopsy for monitoring the Darwinian clonal evolution from an early to a metastatic stage. (C) 2017 S. Karger AG, Basel
机译：癌症是一种空间和颞型动态疾病，不同地发展的遗传克隆是对进展的负责。在这种景观中，可以通过深序代表性空间样本来捕获原发性肿瘤的基因组异质性。然而，识别负责肿瘤演化的遗传改变仍然是一个具有挑战性的任务。最近，“液体活组织检查”被认为是这种动态疾病的分子监测的强大实时方法。术语“液体活检”通常是指使用循环（无细胞）肿瘤DNA（CTDNA）和循环肿瘤细胞（CTC）作为未侵入性生物标志物，用于早期诊断，预后，临床进展监测以及对临床进展的反应在不同类型的肿瘤中治疗，包括高基因组异质乳腺癌。仍然需要两种方法的实施和标准化来实现成功分析异常肿瘤所需的敏感性和特异性，但统计研究，特别是那些关于结直肠癌的致态研究表明，液体活组织检查对于监测达尔文克隆演化的可行性和有用性。早期到转移阶段。 （c）2017年S. Karger AG，巴塞尔

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