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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >ICUS, IDUS, CHIP and CCUS: Diagnostic Criteria, Separation from MDS and Clinical Implications
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ICUS, IDUS, CHIP and CCUS: Diagnostic Criteria, Separation from MDS and Clinical Implications

机译：ICU，IDU，CHIP和CCU：诊断标准，与MDS分离和临床意义

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Various myeloid neoplasms, including the myelodysplastic syndromes (MDS), bear a certain risk of progression to secondary acute myeloid leukemia (sAML). The evolution from low-risk to high-risk MDS and finally to sAML suggests that leukemogenesis is a multistep process. However, even before an overt neoplasm, such as an MDS, develops, "prediagnostic" clonal conditions may be identified. With the advent of large-scale genomic screens, such conditions may be detected quite frequently and early in apparently healthy individuals. Recent data suggest that these conditions increase with age and are indeed associated with an increased risk of the occurrence of MDS or another myeloid neoplasm. In other patients, unexplained cytopenia may be detected and may precede MDS. More recently, diagnostic criteria for potential pre-MDS conditions, including idiopathic cytopenia of uncertain significance and clonal hematopoiesis with indeterminate potential, have been proposed. The current article provides an overview of pre-MDS states and related criteria through which these conditions can be discriminated from each other and from MDS. In addition, the clinical implications and management of pre-MDS states are discussed. (C) 2018 S. Karger AG, Basel
机译：各种骨髓肿瘤，包括骨髓增生综合征（MDS），对次级急性髓性白血病（SAML）具有一定的进展风险。从低风险到高风险MDS的演变，最后到SAML表明白血病是一种多步骤过程。然而，甚至在诸如MDS的明显肿瘤之前，也可以识别出现的“PrediaGnostic”克隆条件。随着大规模基因组屏幕的出现，可能在显然健康的个体中经常和早期检测到这种情况。最近的数据表明，这些条件随着年龄的增长而增加，并且确实与MDS或其他骨髓肿瘤发生的风险增加。在其他患者中，可以检测到未解释的细胞缺乏，并且可以在MDS之前。最近，已经提出了潜在的前MDS病症的诊断标准，包括具有不确定意义和克隆血液具有不确定潜力的特发性细胞凋亡。目前的文章提供了MDS概述的概述和相关标准，通过该标准，这些条件可以彼此区分和来自MDS。此外，还讨论了预先临床意义和管理。 （c）2018年S. Karger AG，巴塞尔

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