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首页> 外文期刊>Pharmaceutical Chemistry Journal >A Study on Essential Oil Chemical Compositions, Antioxidant, and Antimicrobial Activities of Native and Endemic Satureja Species Growing in Iran
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A Study on Essential Oil Chemical Compositions, Antioxidant, and Antimicrobial Activities of Native and Endemic Satureja Species Growing in Iran

机译：生长伊朗生长的原生和地方血清物种的精油化学成分，抗氧化和抗菌活性研究

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摘要

In this study, chemical compositions of the essential oil and antioxidant activities of four Satureja species, namely S. hortensis (SH), S. bachtiarica (SB), S. laxiflora (SL), and S. intermedia (SI) were evaluated. GC and GC/MS were employed to analyze the essential oil samples extracted via hydrodistillation. DPPH and FRAP assays were used to evaluate the radical scavenging and antioxidant properties as well as antimicrobial activities. The GC and GC/MS analysis revealed and identified a total of 25 compounds. The most abundant chemical constituents were rho-cymene (13.07 - 17.50%) in all four species, gamma-terpinene in SL, SH, and SI (11.35 - 37.60%), thymol in SL, SB, and SI (24.54 - 38.75%), and carvacrol in SB and SH (32.07 - 42.51%). The FRAP assay showed that none of the methanol and dichloromethane extracts possessed significant antioxidant activity as compared to quercetin. In addition, the radical scavenging activity of SB and SI methanol extracts were higher than that of SL and SH (DPPH assay). However, all extracts did not show potent radical scavenging activities. It should be noted that this study was the first to evaluate the possible antioxidant or radical scavenging properties of SI and SL. The antimicrobial assay demonstrated a potent activity of all samples against Escherichia coli, Staphylococcus aureus, Candida albicans, Aspergillus fumigatus, and Epidermophyton floccosum (minimum inhibitory concentrations, MIC = 0.06 - 8 mu g/mL). Due to rich content of thymol and carvacrol isomers in Satureja species, they can be suggested for use in various pharmacological applications.
机译：在本研究中，评估了四种Surepja物种的精油和抗氧化剂活性的化学成分，即S. hortensis（Sh），S. bachtiaRiaRica（Sb），S. laxiflora（S1）和S.介质（Si）。使用GC和GC / MS分析通过氢化物提取的精油样品。 DPPH和FRAP测定用于评估自由基清除和抗氧化性能以及抗微生物活性。 GC和GC / MS分析显示并鉴定了总共25种化合物。最丰富的化学成分在所有四种物种，SL，SH和Si（11.35-37.60％），SL，SB和Si中的γ-萜烯（11.35-37.60％），SL，Sb和Si中的rho-cymene（13.07-17.50％）是rho-cymene（13.07-17.50％）（24.54-38.75％ ），和SB和SH中的碳酸（32.07 - 42.51％）。 FRAP测定表明，与槲皮素相比，没有甲醇和二氯甲烷提取物具有显着的抗氧化活性。此外，Sb和Si甲醇提取物的自由基清除活性高于S1和SH（DPPH测定）。然而，所有提取物都没有显示出有效的激进清除活动。应该注意的是，该研究是第一个评价Si和S1的可能的抗氧化剂或自由基清除性质。抗微生物测定证明了对来自大肠杆菌，金黄色葡萄球菌，念珠菌，念珠菌葡萄球菌，曲霉病和表皮咽部的血管藻（最小抑制浓度，MIC =0.06-8μg/ ml）的效率活性。由于Surepja物种中养血管和碳酸钙异构体的丰富含量，可以建议在各种药理应用中使用。

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