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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Comparison of the effects of 1MeTIQ and olanzapine on performance in the elevated plus maze test and monoamine metabolism in the brain after ketamine treatment
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Comparison of the effects of 1MeTIQ and olanzapine on performance in the elevated plus maze test and monoamine metabolism in the brain after ketamine treatment

机译：氯胺酮治疗后脑内升高迷宫试验和单胺代谢性能的比较

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Anxiety is a common symptom of schizophrenia. Ketamine, which acts as a noncompetitive antagonist of glu-tamatergic NMDA receptors by binding to the phencyclidine site, may induce schizophrenia-like symptoms and promote anxiogenic-like behaviour. The symptoms of anxiety in rodents can be measured by the elevated plus maze (EPM) test. 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), as a neuroprotective and antiaddictive substance, produces pharmacological effects by influencing monoaminergic and glutamatergic activity, as previously demonstrated by us. The aim of the present study was to investigate the anxiolytic-like potential of 1MeTIQ after the administration of ketamine. These results were compared to the effects of olanzapine, an antipsychotic drug commonly used in the treatment of schizophrenia. We conducted the EPM test, during which the percentage of time spent in and the number of entries into the open arms were measured. In addition, locomotor activity was measured. Furthermore, we conducted biochemical analyses to verify changes in the levels of neurotransmitters and their metabolites in selected rat brain structures. Behavioural analyses showed that 1MeTIQ, similar to olanzapine, completely inhibited ketamine-induced anxiogenic effects in the EPM test. On the other hand, neurochemical data indicated that 1MeTIQ, as a reversible inhibitor of MAO, significantly blocked the dopamine MAO-dependent oxidation pathway, whereas olanzapine significantly increased the activity of this pathway. The results above suggest that the anxiolytic-like properties of 1MeTIQ are connected to its influence on the catabolism of dopamine, the elevation of serotonin concentrations and the reduction in the levels of noradrenaline.
机译：焦虑是精神分裂症的常见症状。氯胺酮通过结合Phenyclidine位点作为非竞争性拮抗剂，可作为胶合作用的拮抗剂，可以诱导精神分裂症样症状并促进类似焦虑的行为。啮齿动物焦虑的症状可以通过升高的加迷宫（EPM）测试来测量。如前面证明的，1-甲基-1,2,3,4-四羟基喹啉（1METIQ）作为神经保护和抗睡性物质，通过影响单氨基能和谷氨酸谷氨酸活性产生药理作用。本研究的目的是探讨氯胺酮后1METIQ的抗焦虑电位。将这些结果与奥氮平的影响进行了比较，常用于精神分裂症的抗精神病药。我们进行了EPM测试，在此期间测量所花费的时间的百分比和张开臂进入的条目数。此外，测量了运动活性。此外，我们进行了生物化学分析，以验证所选择的大鼠脑结构中神经递质及其代谢物水平的变化。行为分析表明，类似于奥氮平的1METIQ，完全抑制了EPM测试中的氯胺酮诱导的焦虑作用。另一方面，神经化学数据表明，1METIQ作为毛的可逆抑制剂，显着阻断了多巴胺型造物氧化途径，而奥氮藻显着增加了该途径的活性。上述结果表明，1METIQ的抗焦虑状性能与其对多巴胺分解代谢的影响，血清素浓度的升高以及去甲肾上腺素水平的降低。

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