• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Biological profiling of piperazinediones for the management of anxiety
【24h】

Biological profiling of piperazinediones for the management of anxiety

机译：哌嗪的生物分析焦虑管理

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The anxiolytic effect of earlier reported piperazinediones was assessed by elevated plus maze (EPM), hole-board and open-field (OFT) tests. The rats were administered pretreatment of three different doses i.e. 2, 1 and 0.5 mg/kg of compounds 52, 53 and 55 for seven consecutive days. Compound 52 and diazepam showed increase in open arm entries, increase in time spent therein and total arm entries at 1 mg/kg dose. The compound also produced increase in the number of head dip, sniffing behavior and total number of squares crossed compared to diazepam. In OFT paradigm grooming behavior, number of central squares crossed and the time spent in central area did not reveal statistical differences for diazepam and compound 52 at 1 mg/kg dose. Flumazenil mediated antagonism experiments of these showed that they were acting through benzodiazepine site on GABAA receptor. The levels of 5HT and 5HIAA were estimated in amygdalar region. Level of 5HT was found to be equivalent in case of compound 52 and diazepam treatment at dose of 1 mg/kg. Interestingly, compound 52 did not display sedative effect at higher dose in both animal models. Thus, present study indicated that compound 52 produced anti-anxiety property through modulation of GABAergic transmission.
机译：通过升高的加迷宫（EPM），孔板和开放式（OFT）试验评估了早期报告的哌嗪的抗焦虑作用。将大鼠预处理三种不同剂量的预处理，连续七个不同剂量的剂量。2,1和0.5mg / kg化合物52,53和55。化合物52和Diazepam显示出开口臂的增加，其中在其中花费的时间和1mg / kg剂量的总臂入口增加。与DiazePam相比，该化合物还产生了头部倾角，嗅探行为的数量，嗅探行为和横跨的平方数。在OFT范式修饰行为中，中央方块的数量和中央区域所花费的时间没有透露在1mg / kg剂量下的Diazepam和化合物52的统计差异。福兰纳尼介导的拮抗作用表明，它们通过GABAA受体的苯二氮卓遗址作用。在Amygdalar地区估计了5HT和5HIAA的水平。在剂量为1mg / kg的剂量的化合物52和Diazepam处理的情况下，发现5HT的水平是等同的。有趣的是，化合物52在两种动物模型中没有以较高剂量显示镇静效果。因此，目前的研究表明，化合物52通过调节胃肠杆菌传播产生抗焦虑性能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号