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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Multivariate pattern analysis of the neural correlates of smoking cue attentional bias
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Multivariate pattern analysis of the neural correlates of smoking cue attentional bias

机译：吸烟提示偏差神经相关性的多变量模式分析

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The automatic capture of attention by drug cues, or attentional bias, is associated with craving and predicts future drug use. Despite its clinical significance, the neural bases of attentional bias to drug cues is not well understood. To address this gap, we undertook a neuroimaging investigation of the neural correlates of attentional bias towards smoking cues. Twenty-nine adults, including 14 active smokers and 15 non-smokers, completed a spatial cuing task during fMRI. A multivariate pattern analysis (MVPA) decoded the neural responses to the brief presentation of smoking versus neutral images. These data were correlated with behavioral measures of attentional bias, which included analyses targeting the neural correlates of response facilitation and cue-related task interference. We detected a set of brain-behavioral correlates that were similar across both smokers and non-smokers, indicating a role for stimuli salience in the absence of nicotine conditioning in smoking cue attentional bias. However, multiple smoking-related modifications to the neural correlates of attentional bias and its components were also identified. For example, regions demonstrating smoking-related differences in the neural correlates of attentional bias included the rostra] anterior cingulate cortex and inferior frontal gyrus. Response facilitation effects of smoking were observed in the right orbitofrontal gyrus and bilateral middle temporal gyrus. Smoking-cue related task interference was related to smoking-related effects in the frontal eye fields. Our findings suggest that multiple cognitive, affective, and visual object recognition processes contribute to attentional bias towards smoking cues, and suggest multiple circuit modifications that may contribute to perpetuation of addiction.
机译：通过药物提示或注意力偏差自动捕获注意力，与渴望和预测未来的药物使用有关。尽管其临床意义，但毒品提示的神经基地尚未得到很好的理解。为了解决这一差距，我们对吸烟线索的神经关联的神经相关性进行了神经影像研究。 29名成年人，包括14名活跃的吸烟者和15名非吸烟者，在FMRI期间完成了空间Cuing任务。多变量模式分析（MVPA）解码了对吸烟与中性图像的短暂介绍的神经响应。这些数据与注意力偏差的行为测量相关，包括分析靶向响应便利化和相关任务干扰的神经相关性。我们发现了一系列脑行为相关性，这些脑卒中在吸烟者和非吸烟者上具有相似的相关性，表明在吸烟提示偏见的尼古丁调理没有尼古丁调理中的刺激作用作用。然而，还鉴定了对密度偏差和其组分的神经相关性的多次吸烟有关的修饰。例如，展示吸烟有关的差异的地区注意力偏差的神经相关性差异包括rostra]前刺铰接皮质和劣质额相。在右侧眶周转血和双侧中间时颞克鲁斯观察到吸烟的反应促进效果。吸烟相关的任务干扰与额外眼部的吸烟有关。我们的研究结果表明，多种认知，情感和视觉对象识别过程有助于对吸烟线提示的注意力偏差有助于提出多种电路修改，这可能导致成瘾的永久性。

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