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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats.
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Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats.

机译：辅酶Q10显示抗抑郁的活性，并在慢性应激大鼠中减少海马氧化/亚硝酸盐DNA损伤。

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摘要

Multiple evidences suggest that depression is accompanied by an induction of oxidative/nitrosative stress (O&NS) pathways and by a reduced antioxidant status. Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial electron transport pathway and has a powerful antioxidant capacity.This study investigated the effect of chronic treatment with CoQ10 (25, 50, 100 and 150 mg/kg/day, i.p. for 3 weeks) on depressive-like behavior and hippocampal, O&NS, and DNA damage, induced by chronic restraint stress (CRS), an experimental model of depression, in rats.CoQ10 showed a significant antidepressant effect, as evidenced by amelioration of CRS-induced behavioral aberrations in forced swimming and open field tests, elevated corticosterone level and body weight loss. Moreover, CoQ10 dose-dependently restored the hippocampal catalase, glutathione peroxidase and reduced glutathione and decreased the hippocampal malondialdehyde, nitric oxide and 8-hydroxy-2'-deoxyguanosine levels, which indicated a potential protective effect of CoQ10 against hippocampal O&NS lipid peroxidation and DNA damage.CoQ10 possesses antidepressant activity and can protect against CRS-induced hippocampal DNA damage which could be mediated in part by maintaining mitochondrial function and its well documented antioxidant properties. Therefore, CoQ10 may have a potential therapeutic value for the management of depressive disorders. However, further research, is still required to characterize the mechanism of the antidepressant effect of CoQ10 and extend these results before the safe application in humans.
机译：多重证据表明，抑郁症伴有诱导氧化/亚硝酸盐应激（O＆NS）途径和降低的抗氧化剂状态。辅酶Q10（COQ10）是线粒体电子传输途径中的必需辅助因子，具有强大的抗氧化能力。本研究研究了慢性治疗与CAQ10（25,50,100和150mg / kg /天，IP 3周的慢性处理的影响关于抑郁的行为和海马，o＆n和DNA损伤，慢性约束应激（Crs）诱导，抑郁症的实验模型，大鼠.COQ10表现出显着的抗抑郁作用，如CRS引起的行为像差的改善所证明在强制游泳和开放的现场测试中，皮质酮水平升高，体重减轻。此外，COQ10剂量依赖性恢复了海马过氧化物酶，谷胱甘肽过氧化物酶和降低的谷胱甘肽，降低了海马丙二醛，一氧化氮和8-羟基-2'-脱氧樟苷水平，这表明辅酶Q10对海马O＆NS脂质过氧化和DNA的潜在保护作用损伤.COQ10具有抗抑郁活性，可以通过维持线粒体功能及其良好的抗氧化性能，防止CRS诱导的海马DNA损伤。因此，COQ10可能具有抑制性疾病管理的潜在治疗价值。然而，进一步的研究仍然需要表征CoQ10的抗抑郁效应的机制，并在人类安全应用之前延伸这些结果。

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