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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Variable maternal stress in rats alters locomotor activity, social behavior, and recognition memory in the adult offspring.
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Variable maternal stress in rats alters locomotor activity, social behavior, and recognition memory in the adult offspring.

机译：大鼠的可变产妇压力改变了成人后代的运动活动，社会行为和识别记忆。

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Rats repeatedly exposed to variable prenatal stress (PNS) exhibit behavioral signs that are similar to those manifested in several neuropsychiatric disorders such as deficits in attention and inhibitory control, and impairments in memory-related task performance. The purpose of the study described here was to conduct a comprehensive battery of tests to further characterize the behavioral phenotype of PNS rats as well as to evaluate the sensitivity of the model to therapeutic interventions (i.e., to compounds previously shown to have therapeutic potential in neuropsychiatric disorders). The results of this study indicated that PNS in rats is associated with: 1) increased locomotor activity and stereotypic behaviors, 2) elevated sensitivity to the psychostimulant amphetamine, 3) increased aggressive behaviors toward both adult and juvenile rats and 4) delay-dependent deficits in recognition memory. There was no evidence that PNS rats exhibited deficits in other areas of motor function/learning, sensorimotor gating, spatial learning and memory, social withdrawal, or anhedonia. In addition, the results revealed that the second generation antipsychotic risperidone attenuated amphetamine-related increases in locomotor activity in PNS rats; however, the effect was not sustained over time. Furthermore, deficits in recognition memory in PNS rats were attenuated by the norepinephrine reuptake inhibitor, atomoxetine, but not by the α7 nicotinic acetylcholine receptor partial agonist, GTS-21. This study supports the supposition that important phenomenological similarities exist between rats exposed to PNS and patients afflicted with neuropsychiatric disorders thus further establishing the face validity of the model for evaluating potential therapeutic interventions.
机译：反复暴露于可变产前应激（PNS）的大鼠表现出类似于在几种神经精神疾病中表现出的行为迹象，例如在关注和抑制​​控制中的缺陷，以及内存相关的任务性能的损伤。这里描述的研究目的是进行综合测试的测试，以进一步表征PNS大鼠的行为表型以及评估模型对治疗干预的敏感性（即，前面显示在神经精神中具有治疗潜力的化合物障碍）。该研究的结果表明，大鼠中的PNS与：1）流动运动活性和陈规定型行为增加，2）对成人和青少年大鼠的侵袭性增加，3）升高的侵蚀性行为增加，4）升高依赖性缺陷率升高。在识别记忆中。没有证据表明，PNS大鼠在其他电动机函数/学习，传感器门控，空间学习和记忆，社会退出或anhedonia的其他领域呈现缺陷。此外，结果表明，第二代抗精神病药酮减毒了与PNS大鼠运动活性相关的约二酚相关的增加;但是，效果随着时间的推移而不是维持。此外，通过去甲肾上腺素再摄取抑制剂，甲氧酰胺，但不是由α7烟碱乙酰胆碱受体部分激动剂，GTS-21衰减PNS大鼠中识别物中的识别记忆缺陷。本研究支持对暴露于PNS的大鼠和患有神经精神疾病的大鼠之间存在重要的现象学相似性，从而进一步建立了用于评估潜在治疗干预的模型的面部有效性。

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