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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Putative involvement of the nitrergic system on the consolidation, but not initiation, of behavioral sensitization after conspecific alarm substance in zebrafish
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Putative involvement of the nitrergic system on the consolidation, but not initiation, of behavioral sensitization after conspecific alarm substance in zebrafish

机译：硝态物质在斑马鱼中的特异性报警物质后行为致敏的巩固效应

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摘要

Stressful manipulations can sensitize the behavior of an organism, increasing anxiety-like behavior after a delay; this long-term stress sensitization can represent the pathophysiological basis of trauma- and stress-related disorders (TRSDs), of which the most prevalent is post-traumatic stress disorder (PTSD). A role for the glutamate-nitric oxide pathway in this sensitization is implied by behavioral, neurophysiological and genomic data on different species. Here, we report on the long-term sensitization of anxiety-like behavior in zebrafish and the possible participation of nitric oxide in this process. Zebrafish exposed to a conspecific alarm substance (AS) show increased anxiety-like behavior at least 24 h after stimulus delivery. Blocking nitric oxide synthesis with L-NAME (5 mg/kg) 30 min, but not 90 min, after AS exposure blocks the sensitization of scototaxis and risk assessment, while treatment 90 min after exposure blocks the sensitization of thigmotaxis and erratic swimming; L-NAME was not effective when administered 30 min before AS exposure. These data suggest a participation of nitric oxide in the consolidation, but not in the initiation, of behavioral sensitization after predator threat. (C) 2015 Elsevier Inc. All rights reserved.
机译：压力操纵可以敏感生物体的行为，延迟后增加焦虑的行为;这种长期应激敏化可以代表创伤和应激相关疾病（TRSD）的病理生理学基础，其中最普遍的是创伤后应激障碍（PTSD）。在不同物种上的行为，神经生理学和基因组数据暗示了这种致敏中谷氨酸一氧化氮途径的作用。在这里，我们报告了斑马鱼中焦虑的行为的长期致敏，以及在该过程中的一氧化氮的可能参与。斑马鱼暴露于特异性报警物质（AS）显示刺激递送后至少24小时的焦虑状行为增加。通过L-NAME（5mg / kg）30分钟阻断一氧化氮合成，但不是90分钟，因为暴露阻断突科胃和风险评估的敏化，而在暴露后90分钟内容阻止ThiGMotaxis和不稳定游泳的敏化;在曝光前30分钟时，L-NAME无效。这些数据表明在捕食者威胁后的行为致敏中，在整合中的一氧化氮中的参与，但不在启动中。 （c）2015 Elsevier Inc.保留所有权利。

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