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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Putative involvement of the nitrergic system on the consolidation, but not initiation, of behavioral sensitization after conspecific alarm substance in zebrafish
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Putative involvement of the nitrergic system on the consolidation, but not initiation, of behavioral sensitization after conspecific alarm substance in zebrafish

机译：假定亚硝化系统参与了斑马鱼中特定警报物质后行为敏化的巩固而不是启动

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摘要

Stressful manipulations can sensitize the behavior of an organism, increasing anxiety-like behavior after a delay; this long-term stress sensitization can represent the pathophysiological basis of trauma- and stress-related disorders (TRSDs), of which the most prevalent is post-traumatic stress disorder (PTSD). A role for the glutamate-nitric oxide pathway in this sensitization is implied by behavioral, neurophysiological and genomic data on different species. Here, we report on the long-term sensitization of anxiety-like behavior in zebrafish and the possible participation of nitric oxide in this process. Zebrafish exposed to a conspecific alarm substance (AS) show increased anxiety-like behavior at least 24 h after stimulus delivery. Blocking nitric oxide synthesis with L-NAME (5 mg/kg) 30 min, but not 90 min, after AS exposure blocks the sensitization of scototaxis and risk assessment, while treatment 90 min after exposure blocks the sensitization of thigmotaxis and erratic swimming; L-NAME was not effective when administered 30 min before AS exposure. These data suggest a participation of nitric oxide in the consolidation, but not in the initiation, of behavioral sensitization after predator threat. (C) 2015 Elsevier Inc. All rights reserved.
机译：压力操作可以使生物体的行为敏感，并在延迟后增加类似焦虑的行为。这种长期的压力敏感性可以代表创伤和压力相关疾病（TRSD）的病理生理基础，其中最普遍的是创伤后应激障碍（PTSD）。不同物种的行为，神经生理学和基因组数据暗示着谷氨酸一氧化氮途径在这种致敏中的作用。在这里，我们报告的斑马鱼中的焦虑样行为的长期敏化和一氧化氮可能参与此过程。暴露于特定警报物质（AS）的斑马鱼在刺激传递后至少24小时显示出类似焦虑的行为。在AS暴露后30分钟（而不是90分钟）以L-NAME（5 mg / kg）阻止一氧化氮的合成，从而阻止了苏格兰梗概的致敏性和风险评估，而暴露后90 min的治疗则阻止了趋血性和不稳定的游泳。在AS暴露前30分钟服用L-NAME无效。这些数据表明一氧化氮参与捕食者威胁后行为敏化的巩固，但不参与。 （C）2015 Elsevier Inc.保留所有权利。

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