Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone

Jones Jermaine D.; Mumtaz Mudassir; Manubay Jeanne M.; Mogali Shanthi; Sherwin Elliana; Martinez Suky; Comer Sandra D.

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Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone

机译：评估阿片类药物和多巴胺相关的遗传多态性对羟考酮的滥用责任的贡献

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Background: Attempts to identify opioid users at increased risk of escalating to opioid use disorder have had limited success. Data from a variety of sources suggest that genetic variation may mediate the subjective response to opioid drugs, and therefore contribute to their abuse potential. The goal of the current study was to observe the relationship between select genetic polymorphisms and the subjective effects of oxycodone under controlled clinical laboratory conditions.

机译：背景：鉴定对阿片类药物使用障碍升高的风险增加的阿片类药物的成功取得有限。来自各种来源的数据表明遗传变异可能介导对阿片类药物的主观反应，因此有助于其滥用潜力。目前研究的目的是观察选择遗传多态性与羟考酮在受控临床实验室条件下的关系。

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《Pharmacology, Biochemistry and Behavior》 |2019年第2019期|共7页
作者
Jones Jermaine D.; Mumtaz Mudassir; Manubay Jeanne M.; Mogali Shanthi; Sherwin Elliana; Martinez Suky; Comer Sandra D.;
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New York State Psychiat Inst &

Hosp Div Subst Use Disorders 1051 Riverside Dr New York NY 10032;

CUNY City Coll Translat Res Training Program Addict 160 Convent Ave New York NY 10031 USA;

New York State Psychiat Inst &

Hosp Div Subst Use Disorders 1051 Riverside Dr New York NY 10032;

New York State Psychiat Inst &

Hosp Div Subst Use Disorders 1051 Riverside Dr New York NY 10032;

New York State Psychiat Inst &

Hosp Div Subst Use Disorders 1051 Riverside Dr New York NY 10032;

CUNY City Coll Translat Res Training Program Addict 160 Convent Ave New York NY 10031 USA;

New York State Psychiat Inst &

Hosp Div Subst Use Disorders 1051 Riverside Dr New York NY 10032;

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正文语种 eng
中图分类药理学;
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1. Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone [J] . Jones Jermaine D., Mumtaz Mudassir, Manubay Jeanne M., Pharmacology, Biochemistry and Behavior . 2019,第期

机译：评估阿片类药物和多巴胺相关的遗传多态性对羟考酮的滥用责任的贡献
2. The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers. [J] . Walsh SL, Nuzzo PA, Lofwall MR, Drug and alcohol dependence . 2008,第3期

机译：在处方阿片类药物滥用者中评估了口服羟考酮，氢可酮和氢吗啡酮的相对滥用责任。
3. Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism [J] . E Quertemont Molecular Psychiatry . 2004,第6期

机译：乙醇代谢中的遗传多态性：乙醛对酒精滥用和酒精中毒的贡献
4. An Application of CART Algorithm in Genetics: IGFs and cGH Polymorphisms in Japanese Quail [C] . Sel?uk Kaplan International Conference on Advances in Natural and Applied Sciences . 2017

机译：日本鹌鹑遗传学算法在遗传学中的应用：IGFS和CGH多态性
5. Abuse liability of controlled-release oxycodone formulations. [D] . Rafat, Bijan. 2016

机译：控释羟考酮制剂的滥用责任。
6. The Relative Abuse Liability of Oral Oxycodone Hydrocodone and Hydromorphone Assessed in Prescription Opioid Abusers [O] . Sharon L. Walsh, Paul A. Nuzzo, Michelle R. Lofwall, -1

机译：处方阿片类药物滥用者对口服羟考酮氢可酮和氢吗啡酮的相对滥用责任
7. Buprenorphine/naloxone as a promising therapeutic option for opioid abusing patients with chronic pain: reduction of pain, opioid withdrawal symptoms, and abuse liability of oral oxycodone. [O] . Roux Perrine, Sullivan Maria, Cohen Julien, 2013

机译：丁丙诺啡/纳洛酮是治疗阿片类药物慢性疼痛患者的有前途的治疗选择：减轻疼痛，阿片类药物戒断症状和口服羟考酮的滥用倾向。

Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone

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