• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Philosophical Transactions of the Royal Society of London, Series B. Biological Sciences >On transposons and totipotency
【24h】

On transposons and totipotency

机译：关于跨越子和全能性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Our perception of the role of the previously considered 'selfish' or 'junk' DNA has been dramatically altered in the past 20 years or so. A large proportion of this non-coding part of mammalian genomes is repetitive in nature, classified as either satellites or transposons. While repetitive elements can be termed selfish in terms of their amplification, such events have surely been co-opted by the host, suggesting by itself a likely altruistic function for the organism at the subject of such natural selection. Indeed numerous examples of transposons regulating the functional output of the host genome have been documented. Transposons provide a powerful framework for large-scale relatively rapid concerted regulatory activities with the ability to drive evolution. Mammalian totipotency has emerged as one key stage of development in which transposon-mediated regulation of gene expression has taken centre stage in the past few years. During this period, large-scale (epigenetic) reprogramming must be accomplished in order to activate the host genome. In mice and men, one particular element murine endogenous retrovirus with leucine tRNA primer (MERVL) (and its counterpart human ERVL (HERVL)) appears to have acquired roles as a key driving force in this process. Here, I will discuss and interpret the current knowledge and its implications regarding the role of transposons, particularly of long interspersed nuclear elements (LINE-1s) and endogenous retroviruses (ERVs), in the regulation of totipotency.
机译：我们对过去20年左右的前面被认为的“自私”或“垃圾”DNA的作用的看法已大大改变。哺乳动物基因组的这种非编码部分的大部分是在自然中重复的，分类为卫星或转座子。虽然重复的元素可以在扩增方面被称为自私，但是这种事件肯定是由宿主共同选择的，而是本身暗示了这种自然选择的受试者的生物体的可能存在的利他功能。实际上，已经记录了调节宿主基因组功能输出的转座子的许多实例。转座子为大规模相对快速的协调监管活动提供了强大的框架，具有推动进化的能力。哺乳动物Totipotency已成为一个关键阶段的发展，其中转座介导的基因表达调控在过去几年中占据了中心阶段。在此期间，必须实现大规模（表观遗传）重编程以激活宿主基因组。在小鼠和男性中，一种特定的元素鼠内源性逆转录病毒具有亮氨酸TRNA引物（Merv1）（及其对应人ERVL（HERVL））似乎已经获得了该过程中作为关键驱动力的角色。在这里，我将讨论和解释目前的知识及其关于转座子的作用的影响，特别是在彻特语调节中，尤其是长三个核元素（第1次）和内源性逆转录病毒（ERV）的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号