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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >Mahanine, A dietary phytochemical, represses mammary tumor burden in rat and inhibits subtype regardless breast cancer progression through suppressing self-renewal of breast cancer stem cells
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Mahanine, A dietary phytochemical, represses mammary tumor burden in rat and inhibits subtype regardless breast cancer progression through suppressing self-renewal of breast cancer stem cells

机译：Mahanine，膳食植物化学，抑制大鼠乳腺肿瘤负荷，并通过抑制乳腺癌干细胞的自我更新来抑制乳腺癌进展的乳腺癌进展

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摘要

Mahanine (MH), a carbazole alkaloid isolated from an edible plant (Murraya koenigii), potentially inhibits the growth of altered subtypes of breast cancer cells in vitro and significantly reduced the mammary tumor burden in N-Methyl-N-nitrosourea (MNU) induced rat. The experimental results showed that 20-25 tiM of MH for 24 h of treatment was very potent to reduce the cell proliferation through apoptosis with arresting the cells in G(0)/G(1) in both ER+ /p53(WT) MCF-7 and triple negative/p53(Mut) MDA-MB-231 cells. On the other hand, 10-15 mu M of MH exposure to those two cell lines, caused inhibition of mammosphere formation and reduction of CD44(high)/CD24(low)/epithelial-specific antigen-positive (ESA +) population, which ultimately led to loss of self-renewal ability of breast cancer stem cells. Further, in vivo observation indicated that intraperitoneal injection of MH for four weeks with a dose of 50 mg/kg body weight thrice in a week, significantly (P = 0.03) reduced the mammary tumor weight in MNU induced rat. In conclusion, this study provides the novel insight into the mechanism of MH mediated growth arrest in subtype irrespective breast cancer progression.
机译：Mahanine（MH），一种从食用植物中分离的咔唑生物碱（Murraya Koenigii），可能抑制体外乳腺癌细胞亚型改变的亚型的生长，显着降低了N-甲基-N-硝基脲（MNU）的乳腺肿瘤负荷鼠。实验结果表明，24小时的20-25次治疗方法非常有效，以通过凋亡降低细胞增殖，在ER + / P53（WT）MCF中捕获G（0）/ g（1）中的细胞7和三重阴性/ p53（mut）MDA-MB-231细胞。另一方面，10-15亩MH暴露于这两种细胞系，导致乳腺圈形成的抑制和CD44（高）/ CD24（低）/上皮特异性抗原阳性（ESA +）人群的抑制作用最终导致乳腺癌干细胞的自我更新能力失去。此外，在体内观察中表明，在一周内具有50mg / kg体重三周的腹腔注射4周，显着（p = 0.03）降低了MNU诱导大鼠的乳腺肿瘤重量。总之，本研究提供了对乳腺癌进展无关亚型亚型MH介导的生长阻滞机制的新颖洞察力。

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