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首页> 外文期刊>Pharmacology and Therapeutics: The Journal of the International Encyclopedia of Pharmacology and Therapeutics >Cancer immunotherapy with immunoadjuvants, nanoparticles, and checkpoint inhibitors: Recent progress and challenges in treatment and tracking response to immunotherapy
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Cancer immunotherapy with immunoadjuvants, nanoparticles, and checkpoint inhibitors: Recent progress and challenges in treatment and tracking response to immunotherapy

机译：癌症免疫疗法，纳米粒子和检查点抑制剂：近期治疗和跟踪免疫疗法的进展和挑战

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摘要

Chemotherapy, surgery, and radiation are accepted as the preferred treatment modalities against cancer, but in recent years the use of immunotherapeutic approaches has gained prominence as the fourth treatment modality in cancer patients. In this approach, a patient's innate and adaptive immune systems are activated to achieve clearance of occult cancerous cells. In this review, we discuss the preclinical and clinical immunotherapeutic (e.g., immunoadjuvants (in-situ vaccines, oncolytic viruses, CXC antagonists, device activated agents), organic and inorganic nanopartides, and checkpoint blockade) that are under investigation for cancer therapy and diagnostics. Additionally, the innovations in imaging of immune cells for tracking therapeutic responses and limitations (e.g., toxicity, inefficient immunomodulation, etc.) are described. Existing data suggest that if immune therapy is optimized, it can be a real and potentially paradigm-shifting cancer treatment frontier. (C) 2019 Elsevier Inc. All rights reserved.
机译：化学疗法，手术和辐射被认为是对癌症的优选治疗方式，但近年来，免疫治疗方法的使用已经突出作为癌症患者的第四种治疗方式。在这种方法中，激活患者的先天和适应性免疫系统以实现隐匿性癌细胞的间隙。在本次综述中，我们讨论了正在研究癌症治疗和诊断的临床前和临床免疫治疗型（例如，免疫呼吸（原位疫苗，溶解疫苗，CXC拮抗剂，装置活化剂），有机和无机纳米醇和检查点封闭件） 。另外，描述了用于跟踪治疗反应和限制（例如，毒性，低效免疫调节等）的免疫细胞成像的创新。现有数据表明，如果优化免疫疗法，则可以是一个真实且潜在的范式转移的癌症治疗前沿。 （c）2019 Elsevier Inc.保留所有权利。

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