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首页> 外文期刊>Physiology & behavior >Effects of inactivation of the ventral tegmental area on prefronto-accumbens activity and sexual motivation in male rats
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Effects of inactivation of the ventral tegmental area on prefronto-accumbens activity and sexual motivation in male rats

机译：腹侧腹膜灭活面积对雄性大鼠前肠球菌活性和性动机的影响

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摘要

Sexual motivation requires the processing of sexual stimuli. The prefrontal cortex (PFC) and nucleus accumbens (NAcc) receive dopaminergic innervation from the ventral tegmental area (VTA). Both structures participate in processing stimuli, and their adequate functioning is modulated by dopamine and other neurotransmitters. This study was designed to determine the effect of inactivation of the VTA on sexual motivation, relative power (RP) and electroencephalographic (EEG) correlation of the PFC and NAcc in male rats. A total of 20 rats implanted with electrodes in the left medial prefrontal cortex (mPFC) and NAcc, and with bilateral cannulae in the VTA, were divided into two groups of 10 rats each, one injected with tetrodotoxin (TTX), the other with a vehicle solution (VEH). EEGs from the mPFC and NAcc were recorded during the awake-quiet state in the presence of either a receptive or non-receptive female. The TTX group showed a lower preference for the receptive female accompanied by a lower RP of the 8-13 and 14-30 Hz bands in the mPFC. Also, in the presence of the receptive female, the TTX group had a lower RP of the 8-13 Hz band in the NAcc, but a higher prefronto-accumbens correlation in the same band. These results provide evidence that VTA activity is necessary for the adequate functioning of the mPFC and NAcc and, therefore, also for the adequate processing of sexually-relevant stimuli that allows the induction and maintenance of sexual motivation in male rats.
机译：性动机需要处理性刺激。前额叶皮质（PFC）和核常压（NACC）从腹侧三腭区域（VTA）接受多巴胺能物质。这两种结构参与加工刺激，并通过多巴胺和其他神经递质调节其充分的功能。本研究旨在确定VTA对雄性大鼠PFC和NACC的性动力，相对功率（RP）和脑电图（EEG）相关性的灭活效果。在左侧内前列前皮质皮质（MPFC）和NACC中植入电极的总共20只大鼠，并且在VTA中用双侧套管分为两组10只大鼠，一个注射四胞毒素（TTX），另一种车辆解决方案（VEL）。在存在接受或非接受女性的情况下，在醒着安静状态期间记录来自MPFC和NACC的脑电图。 TTX基团表明，对MPFC中8-13和14-30Hz带的低RP伴随的接受雌性的偏好。此外，在接受雌性存在下，TTX基团在NACC中具有8-13Hz带的较低RP，但在同一频段中具有更高的前差 - uncumbens相关性。这些结果提供了证据，即VTA活动对于MPFC和NACC的充分运作是必要的，因此，还用于对性相关刺激的充分处理，允许归类和维持雄性大鼠的性动机。

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