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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >Inactivation of the medial preoptic area/anterior hypothalamus by lidocaine reduces male sexual behavior and sexual incentive motivation in male rats.
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Inactivation of the medial preoptic area/anterior hypothalamus by lidocaine reduces male sexual behavior and sexual incentive motivation in male rats.

机译：利多卡因使视前内侧区/下丘脑前部失活会降低雄性大鼠的雄性行为和性动机。

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摘要

Permanent bilateral lesions of the medial preoptic area anterior hypothalamus (MPOA/AH) produce a drastic inhibition of male sexual behavior in all species studied to date. The present experiment was designed to evaluate if temporal inactivation of the MPOA/AH by infusions of lidocaine also inhibits sexual behavior in male rats. This would allow us to rule out the possibility that the behavioral effects observed after damage of the MPOA/AH could be associated with plastic changes induced by the lesion in other brain regions. We also evaluated sexual incentive motivation in males after the infusion of lidocaine in a test in which copulation is not possible but where males maintain approach behavior to the estrous females despite repeated testing. The percentage of animals displaying mounts, intromissions and ejaculation was significantly reduced while mount and intromission latency were prolonged after infusion of lidocaine. No changes were observed in sexual behavior after infusion of lidocaine in animals with cannulae outside the MPOA/AH suggesting that the inhibitory effects are specific to this brain region. Sexual incentive motivation was also affected by administration of lidocaine. Males consistently showed a clear preference for the sexually receptive female except when infused with lidocaine. After the infusion of the compound a significant reduction in the time spent in the incentive zone of the stimulus female was observed. These results support the hypothesis that neurons of the MPOA/AH are involved in the control of male sexual motivation.
机译：迄今为止，在所有物种中，视前内侧丘脑下丘脑永久性双侧病变（MPOA / AH）对男性的性行为产生了强烈的抑制作用。本实验旨在评估通过输注利多卡因对MPOA / AH的暂时失活是否也抑制雄性大鼠的性行为。这将使我们排除在MPOA / AH损伤后观察到的行为影响可能与其他脑区域病变引起的可塑性变化有关的可能性。我们还评估了输注利多卡因后男性的性刺激动机，该试验不可能进行交配，但尽管反复试验，男性仍保持对发情女性的接近行为。注入利多卡因后，表现出坐骑，入睡和射精的动物百分比显着降低，而坐骑和入睡潜伏期延长。在动物体内注入MPOA / AH以外的套管的利多卡因后，未观察到性行为的变化，表明该抑制作用对该大脑区域具有特异性。性刺激的动机也受到利多卡因管理的影响。男性始终表现出明显的性接受女性的意愿，除非注入了利多卡因。注入化合物后，观察到在刺激女性的刺激区域中花费的时间显着减少。这些结果支持了MPOA / AH神经元参与男性性动机控制的假设。

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