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The emerging role of liquid biopsy in diagnosis, prognosis and treatment monitoring of pancreatic cancer

机译:液体活检在胰腺癌诊断,预后和治疗监测中的新兴作用

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摘要

Circulating tumor DNA, circulating tumor cells and tumor-related exosomes may offer new opportunities to provide insights into the biological and clinical characteristics of a neoplastic disease. They represent alternative routes for diagnostic and prognostic purposes, and for predicting and longitudinally monitoring response to treatment and disease progression. Hence, circulating biomarkers represent promising noninvasive tools in the scenario of pancreatic cancer, where neither molecular nor clinical predictors of treatment benefit have been identified yet.This review aims to provide an overview of the current status of circulating biomarker research in pancreatic cancer, and discusses their potential clinical utility to facilitate clinical decision-making.
机译:循环肿瘤DNA,循环肿瘤细胞和肿瘤相关的外泌体可以提供新的机会,以便为肿瘤疾病的生物学和临床特征提供见解。 它们代表诊断和预后目的的替代路线,以及预测和纵向监测治疗和疾病进展的响应。 因此,循环生物标志物代表胰腺癌情景中有前途的非侵入性工具,其中既没有发现治疗效益的分子和临床预测因子。此综述旨在概述胰腺癌中循环生物标志物研究的现状,并讨论 他们潜在的临床效用,以促进临床决策。

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