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首页> 外文期刊>Pharmacogenomics >NAT2 slow acetylator is associated with anti-tuberculosis drug-induced liver injury severity in indonesian population
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NAT2 slow acetylator is associated with anti-tuberculosis drug-induced liver injury severity in indonesian population

机译：NAT2慢乙酰乙酰乙酰剂与印度尼西亚人群的抗结核药物诱导的肝损伤严重相关

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摘要

Aim: We investigated the contribution of NAT2 variants and acetylator status to anti-tuberculosis drug-induced liver injury (AT-DILI) severity. Materials & methods: 100 patients with clinically severe AT-DILI and 210 non-AT-DILI controls were subjected to NAT2 genotyping by direct DNA sequencing. Results: NAT2 slow acetylator was significantly associated with AT-DILI risk (p = 2.7 x 10(-7); odds ratio [95% CI] = 3.64 [2.21-6.00]). Subgroup analysis of NAT2 ultra-slow acetylator revealed a stronger association with AT-DILI risk (p = 4.3 x 10(-6); odds ratio [95% CI] = 3.37 [2.00-5.68]). Subset analysis of NAT2 acetylator status and severity grade confirmed these results in AT-DILI patients with more severe disease whereas fast and intermediate acetylator phenotypes were associated with a decreased AT-DILI risk. Conclusion: We elucidated the role of NAT2 phenotypes in AT-DILI in Indonesian population, suggesting that NAT2 genotype and phenotype determination are important to reduce AT-DILI risk.
机译：目的：我们调查了NAT2变体和乙酰物状态对抗结核病药物诱导的肝损伤（AT-DILI）严重程度的贡献。材料和方法：通过直接DNA测序对100名临床严重的临床严重和210例非AT-DILI对照进行NAT2基因分型。结果：NAT2慢乙酰乙酰乙酰乙酰剂与达到帝力风险显着相关（P = 2.7×10（-7）;差距[95％CI] = 3.64 [2.21-6.00]）。 NAT2超慢乙酰乙酰胞胎亚组分析显示出与in-DiLi风险更强的关联（P = 4.3×10（-6）;差距[95％Ci] = 3.37 [2.00-5.68]）。 NAT2乙酰剂状态和严重程度的子集分析证实了这些结果在患有更严重的疾病的患者中，而快速和中间乙酰乙酰型表型与AT-DILI风险降低有关。结论：我们阐明了NAT2表型在印度尼西亚人群中in-Dili的作用，表明NAT2基因型和表型测定对于降低帝力风险很重要。

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