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GWAS analysis of treatment resistant schizophrenia: interaction effect of childhood trauma

机译：治疗抗性精神分裂症的GWAS分析：儿童创伤的相互作用

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Aims: In the current study, we aimed to compare the prevalence of adverse lifetime events in treatment resistant and non-treatment resistant schizophrenia in a genome-wide association study. Materials & methods: Our sample consisted of 84 Caucasian participants with schizophrenia spectrum disorders, assessed cross-sectionally to collect information regarding drug effectiveness and childhood trauma. Using a genome-wide association analysis, we tested single-nucleotide polymorphisms for their association with resistance to antipsychotics defined according to American Psychiatric Association criteria. Two models were tested: a main model and an interaction model with the childhood trauma. Results: Our analysis failed to demonstrate a significant relationship among 1,178,234 single-nucleotide polymorphisms and treatment-resistance in both the main model and in the childhood trauma interaction model. Conclusion: Even though we could not find any significant association, treatment resistance has clinical relevance and it may be determined by the interaction between biological and non biological factors.
机译：目的：在目前的研究中，我们旨在比较在基因组 - 宽协会研究中治疗抗性和非治疗性精神分裂症的不良终身事件的患病率。材料和方法：我们的样品由84名高加索参与者组成，具有精神分裂症谱系障碍，横向评估以收集有关药物效果和儿童创伤的信息。使用基因组关联分析，我们测试了单核苷酸多态性，其与根据美国精神病关联标准定义的抗精神病药的抗性的单核苷酸多态性。测试了两种模型：具有儿童创伤的主要模型和交互模型。结果：我们的分析未能在主要模型和儿童创伤相互作用模型中表现出1,178,234个单核苷酸多态性和治疗抗性之间的显着关系。结论：尽管我们找不到任何重要的关联，但治疗抵抗具有临床相关性，并且可以通过生物学和非生物因素之间的相互作用来确定。

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