Pharmacoepigenomics of opiates and methadone maintenance treatment: current data and perspectives

Marie-Claire Cynthia; Jourdaine Clement; Lepine Jean-Pierre; Bellivier Frank; Bloch Vanessa; Vorspan Florence

首页> 外文期刊>Pharmacogenomics >Pharmacoepigenomics of opiates and methadone maintenance treatment: current data and perspectives

【24h】

Pharmacoepigenomics of opiates and methadone maintenance treatment: current data and perspectives

机译：Apiates和Methadone维护治疗的药物高温：当前数据和观点

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Current treatments of opioid addiction include primarily maintenance medications such as methadone. Chronic exposure to opiate and/or long-lasting maintenance treatment induce modulations of gene expression in brain and peripheral tissues. There is increasing evidence that epigenetic modifications underlie these modulations. This review summarizes published results on opioid-induced epigenetic changes in animal models and in patients. The epigenetic modifications observed with other drugs of abuse often used by opiate abusers are also outlined. Specific methadone maintenance treatment induced epigenetic modifications at different treatment stages may be combined with the ones resulting from patients' substance use history. Therefore, research comparing groups of addicts with similar history and substances use disorders but contrasting for well-characterized treatment phenotypes should be encouraged.

机译：目前对阿片类成瘾的治疗主要包括维持药物如美沙酮。慢性暴露于阿片和/或长期维持治疗诱导脑和外周组织中基因表达的调节。越来越多的证据表明表观遗传修饰利于这些调制。本综述总结了出版的结果对阿片类药物诱导的动物模型和患者的表观遗传变化。还概述了用其他滥用药物观察到的表观遗传修饰，通常概述了印章滥用者使用的滥用药物。特异性美沙酮维持治疗诱导在不同治疗阶段的表观遗传修饰可以与患者物质使用历史的患者组合。因此，应鼓励对与类似历史和物质使用疾病的成瘾者组进行研究，但应鼓励对对比的治疗表型对比。

著录项

来源
《Pharmacogenomics》 |2017年第14期|共14页
作者
Marie-Claire Cynthia; Jourdaine Clement; Lepine Jean-Pierre; Bellivier Frank; Bloch Vanessa; Vorspan Florence;
展开▼
作者单位

Univ Paris 05 Fac Pharm Paris INSERM Variabilite Reponse Psychotropes U1144 Univ Sorbo Paris;

GH St Louis Lariboisiere F Widal AP HP Pole Psychiat &

Med Addictol F-75475 Paris 10 France;

GH St Louis Lariboisiere F Widal AP HP Pole Psychiat &

Med Addictol F-75475 Paris 10 France;

Univ Paris 05 Fac Pharm Paris INSERM Variabilite Reponse Psychotropes U1144 Univ Sorbo Paris;

Univ Paris 05 Fac Pharm Paris INSERM Variabilite Reponse Psychotropes U1144 Univ Sorbo Paris;

Univ Paris 05 Fac Pharm Paris INSERM Variabilite Reponse Psychotropes U1144 Univ Sorbo Paris;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
DNA methylation; drugs of abuse; epigenetics; heroin; methadone;

机译：DNA甲基化;滥用药物;表观学;海洛因;美沙酮;

相似文献

外文文献
中文文献
专利

1. Pharmacoepigenomics of opiates and methadone maintenance treatment: current data and perspectives [J] . Marie-Claire Cynthia, Jourdaine Clement, Lepine Jean-Pierre, Pharmacogenomics . 2017,第14期

机译：Apiates和Methadone维护治疗的药物高温：当前数据和观点
2. Simultaneous liquid chromatography-mass spectrometry quantification of urinary opiates, cocaine, and metabolites in opiate-dependent pregnant women in methadone-maintenance treatment. [J] . Shakleya DM, Dams R, Choo R Journal of Analytical Toxicology . 2010,第1期

机译：同质液相色谱 - 质谱定量尿锁，可卡因和代谢产物在阿甲酸糖依赖性孕妇中的依赖孕妇。
3. Older adults prescribed methadone: A review of the literature across the life span from opiate initiation to methadone maintenance treatment [J] . CentreforAddictionandMentalHealth60WhiteSquirrelWayToronto Current drug abuse reviews. . 2014,第3期

机译：老年人开具美沙酮处方：从鸦片制剂到美沙酮维持治疗的整个生命周期文献回顾
4. The Correlation Between Attitudes Toward HIV/AIDS Transmission Through the Use of Syringes and the Type of Dropout Among the Participants of Methadone Maintenance Treatment [C] . Risnawati, Muchlis AU Sofro, Dendi Durahman, International Conference on Community Health . 2020

机译：艾滋病毒/艾滋病传播态度与美沙酮维持治疗参与者中的辍学类型的态度与艾滋病毒传播的相关性
5. The Comparison of Prescriptions Dispensed For Methadone Maintenance Patients to Non-Methadone Maintenance Patients for the Treatment of Chronic Diseases using PharmaNet Data [D] . Maruyama, Anna. 2012

机译：使用PharmaNet数据比较美沙酮维持治疗患者和非美沙酮维持治疗患者治疗慢性疾病的处方比较
6. Simultaneous Liquid Chromatography–Mass Spectrometry Quantification of Urinary Opiates Cocaine and Metabolites in Opiate-Dependent Pregnant Women in Methadone-Maintenance Treatment [O] . Diaa M. Shakleya, Riet Dams, Robin E. Choo, -1

机译：液相色谱-质谱联用定量分析美沙酮维持治疗中阿片依赖孕妇的尿中阿片可卡因和代谢产物
7. Detection of Opiate Use in a Methadone Maintenance Treatment Population with the CEDIA(R) 6-Acetylmorphine and CEDIA DAU Opiate Assays [O] . A. C. Spanbauer, S. Casseday, D. Davoudzadeh, 2001

机译：检测含有细胞（R）6-乙酰常附胞嘧啶和核苷酸甲酰胺的阿卡替饲养治疗人口中的阿片类药物

Pharmacoepigenomics of opiates and methadone maintenance treatment: current data and perspectives

摘要

著录项

相似文献

相关主题

期刊订阅