Pharmacogenetics may influence the impact of inflammation on voriconazole trough concentrations

Gautier-Veyret Elodie; Bailly Sebastien; Fonrose Xavier; Tonini Julia; Chevalier Simon; Thiebaut-Bertrand Anne; Stanke-Labesque Francoise

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Pharmacogenetics may influence the impact of inflammation on voriconazole trough concentrations

机译：药物发生可能影响炎症对伏立康唑槽浓度的影响

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How pharmacogenetics modulates the inhibitory effects of inflammation on voriconazole trough concentration (Cmin) remains unknown. In 29 recipients of allogeneic hematopoietic stem cell transplantation retrospectively studied, both a genetic score (which aggregated CYP2C19 and CYP3A genotypes) and inflammation significantly influenced voriconazole Cmin (n = 260). A trend toward (p = 0.03) a greater impact of inflammation in patients with the highest genetic score (corresponding to ultra-rapid metabolizers) was observed. Further researches are needed to confirm these data.

机译：药物原理如何调节炎症对伏立康唑槽浓度（CMIN）的抑制作用仍然未知。在29例因异种造血干细胞移植的接受者回顾性研究，遗传分数（聚合CYP2C19和CYP3A基因型）和炎症显着影响了伏立康唑CMIN（n = 260）。（P = 0.03）趋势令炎症在遗传评分最高（对应于超快速代谢剂）中的巨大影响。需要进一步的研究来确认这些数据。

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来源
《Pharmacogenomics》 |2017年第12期|共5页
作者
Gautier-Veyret Elodie; Bailly Sebastien; Fonrose Xavier; Tonini Julia; Chevalier Simon; Thiebaut-Bertrand Anne; Stanke-Labesque Francoise;
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作者单位

CHU Grenoble Alpes Lab Pharmacol Toxicol CS 10217 F-38043 Grenoble 9 France;

Univ Grenoble Alpes HP2 F-38041 Grenoble France;

CHU Grenoble Alpes Lab Pharmacol Toxicol CS 10217 F-38043 Grenoble 9 France;

CHU Grenoble Alpes Lab Pharmacol Toxicol CS 10217 F-38043 Grenoble 9 France;

CHU Grenoble Alpes Lab Pharmacol Toxicol CS 10217 F-38043 Grenoble 9 France;

CHU Grenoble Alpes Lab Pharmacol Toxicol CS 10217 F-38043 Grenoble 9 France;

CHU Grenoble Alpes Lab Pharmacol Toxicol CS 10217 F-38043 Grenoble 9 France;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
CYP2C19; CYP3A4; inflammation; pharmacogenetics; therapeutic drug monitoring; voriconazole;

机译：CYP2C19;CYP3A4;炎症;药物发生;治疗药物监测;伏立康唑;

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1. Pharmacogenetics may influence the impact of inflammation on voriconazole trough concentrations [J] . Gautier-Veyret Elodie, Bailly Sebastien, Fonrose Xavier, Pharmacogenomics . 2017,第12期

机译：药物发生可能影响炎症对伏立康唑槽浓度的影响
2. The effect of inflammation on voriconazole trough concentrations in children [J] . Avest, Mendy, Veringa, British journal of clinical pharmacology . 2017,第3期

机译：炎症对儿童伏立康唑谷浓度的影响
3. Longitudinal Analysis of the Effect of Inflammation on Voriconazole Trough Concentrations [J] . Ventura M. A. Encalada, van Wanrooy M. J. P., Span L. F. R., Antimicrobial agents and chemotherapy. . 2016,第5期

机译：炎症对伏立康唑槽浓度的影响的纵向分析
4. Size and the concentration of wear debris UHMWPE particles influence local inflammation and bone resorption [C] . S. -Y. Yang, H. -W. Fang, K. Siddiqi, Annual meeting of the Society For Biomaterials . 2003

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5. Biogeochemical arsenic cycling influenced by a rainfall-runoff event in an anthropogenically contaminated surface-water system: Impacts on concentration, speciation and toxicity [D] . Markley, Christopher Thomas 2007

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6. Combined Impact of Inflammation and Pharmacogenomic Variants on Voriconazole Trough Concentrations: A Meta-Analysis of Individual Data [O] . Léa Bolcato, Charles Khouri, Anette Veringa, 2021

机译：炎症和药物变异变异对伏立康唑槽浓度的综合影响：个别数据的META分析
7. Combined Impact of Inflammation and Pharmacogenomic Variants on Voriconazole Trough Concentrations: A Meta-Analysis of Individual Data [O] . Léa Bolcato, Charles Khouri, Anette Veringa, 2021

机译：炎症和药物变异变异对伏立康唑槽浓度的综合影响：个别数据的META分析

Pharmacogenetics may influence the impact of inflammation on voriconazole trough concentrations

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