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首页> 外文期刊>Planta medica: Natural products and medicinal plant research >Lipid Nanocarriers for Oral Delivery of Serenoa repens CO (2) Extract: A Study of Microemulsion and Self-Microemulsifying Drug Delivery Systems
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Lipid Nanocarriers for Oral Delivery of Serenoa repens CO (2) Extract: A Study of Microemulsion and Self-Microemulsifying Drug Delivery Systems

机译：脂质纳米载体用于口服促进塞酚蛋白克扣CO（2）提取物：微乳液和自我微乳化药物递送系统的研究

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摘要

The aim of this study was the development and characterization of lipid nanocarriers using food grade components for oral delivery of Serenoa repens CO (2) extract, namely microemulsions (MEs) and self-microemulsifying drug delivery systems (SMEDDSs) to improve the oral absorption. A commercial blend (CB) containing 320 of S. repens CO (2) extract plus the aqueous soluble extracts of nettle root and pineapple stem was formulated in two MEs and two SMEDDSs. The optimized ME loaded with the CB (CBM2) had a very low content of water (only 17.3%). The drug delivery systems were characterized by dynamic light scattering, transmission electron microscopy, and high-performance liquid chromatography (HPLC) with a diode-array detector analyses in order to evaluate the size, the homogeneity, the morphology, and the encapsulation efficiency. -carotene was selected as marker for the quantitative HPLC analysis. Additionally, physical and chemical stabilities were acceptable during 3wk at 4 degrees C. Stability of these nanocarriers in simulated stomach and intestinal conditions was proved. Finally, the improvement of oral absorption of S. repens was studied in vitro using parallel artificial membrane permeability assay. An enhancement of oral permeation was found in both CBM2 and CBS2 nanoformulations comparing with the CB and S. repens CO (2) extract. The best performance was obtained by the CBM2 nanoformulation (17%) predicting a 30-70% passive oral human absorption in vivo .
机译：本研究的目的是利用食品级组分使用食品级组分的脂质纳米载体的开发和表征，用于口服乳头释放CO（2）提取物，即微乳液（MES）和自我微乳化药物递送系统（SMEDDS）以改善口服吸收。将含有320个S. Repens Co（2）提取物加上荨麻植物和菠萝茎的水溶性提取物的商业共混物（Cb）在两个MES和两个Smedds中配制。加载CB（CBM2）的优化我的水含量非常低（仅17.3％）。通过动态光散射，透射电子显微镜和高性能液相色谱（HPLC）的特征在于具有二极管阵列检测器分析的药物递送系统，以评估尺寸，均匀性，形态和封装效率。 - 用于定量HPLC分析的标记为标志物。另外，在4摄氏度的3WK期间，在3WK期间可以接受物理和化学稳定性。证明了这些纳米载体在模拟胃和肠道条件下的稳定性。最后，使用平行人工膜渗透性测定法在体外研究了S. Repens的口服吸收的改善。在CBM2和CBS2纳米型中发现了口服渗透的增强，与CB和S. Repens CO（2）提取物相比。通过CBM2纳米型（17％）获得最佳性能（17％），预测体内30-70％被动口服的人类吸收。

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