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首页> 外文期刊>Social cognitive and affective neuroscience >Capacity for upregulation of emotional processing in psychopathy: all you have to do is ask
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Capacity for upregulation of emotional processing in psychopathy: all you have to do is ask

机译：对精神病病变的上调情绪加工能力：你所要做的就是问

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Historically, psychopathic individuals have been described as suffering a chronic hyporesponsivity to negatively valent stimuli. However, while a wide body of empirical work indicates that the psychopath does not manifest normal reactivity to emotional stimuli, it does not similarly indicate that they cannot do so. To attempt to differentiate these alternatives, the current functional magnetic resonance imaging (fMRI) study evaluated the extent to which offenders with varying PCL-R scores could up- (or down-) regulate their neural response to negatively valent stimuli. Participants were asked to either watch negatively- and neutrally-valent images naturally (passive-processing), or to try to increase or decrease their emotional response to the images (instructed-processing). During passive processing, high-psychopathy offenders showed reduced activity compared to both low- and mid-psychopathic offenders through a majority of emotion-relevant regions. However, when participants were instructed to try to increase their emotional response all groups showing increased activity throughout relevant regions, including left insula, orbitofrontal cortex and anterior cingulate/medial frontal cortex (ACC/mFC). Comparison of participants' subjective emotion ratings indicated that all groups showed symmetry between their neural/subjective emotion metrics, and the high-psychopathy group may have showed the greatest such symmetry. These findings suggest that psychopathic individuals may be capable of manifesting emotional reactivity to negatively valent stimuli, at least under certain conditions. Relevance for traditional and developing models of psychopathy is discussed in turn.
机译：从历史上看，精神疗法人员被描述为患有对负面价值刺激的慢性低位性。然而，虽然宽的经验工作表明，精神病患者没​​有表现出对情绪刺激的正常反应性，但它​​并没有同样表明他们不能这样做。为了尝试区分这些替代方案，目前的功能磁共振成像（FMRI）研究评估了不同PCL-R分数的冒犯者的程度可以提高（或下降）调节它们对负性价值刺激的神经反应。将参与者被要求自然地观看否定和中立的图像，或者尝试增加或减少对图像的情绪响应（指示处理）。在被动加工期间，通过大多数情感相关的地区，高精神病犯罪者与低精神病犯罪者相比表现出减少的活动。然而，当参与者被指示试图增加他们的情绪反应时，所有群体显示出在相关地区的含量增加的活动，包括左侧Insula，Orbitofrontal皮质和前刺刺术/内侧载体（ACC / MFC）。参与者的主观情感评级的比较表明，所有基团在其神经/主观情感度量之间显示对称性，并且高精神病学团体可能表现出最大的这种对称性。这些研究结果表明，至少在某些条件下，精神病患者可能能够表现出对抗性的刺激性的情感反应性。反过来又讨论了对心理疗病的传统和发展模型的相关性。

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