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首页> 外文期刊>Polymers for advanced technologies >Biodegradable and antibacterial poly(azomethine-urethane)-chitosan hydrogels for potential drug delivery application
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Biodegradable and antibacterial poly(azomethine-urethane)-chitosan hydrogels for potential drug delivery application

机译：可生物降解和抗菌聚（偶氮甲基氨基甲酸酯） - 用于潜在药物递送应用的硫醇水凝胶

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In this study, biodegradable and antibacterial poly(azomethine-urethane) (PAMU)- and chitosan (CS)-based hydrogels have been prepared for controlled drug delivery applications. Structural and morphological characterizations of the hydrogels were performed via Fourier transform-infrared and scanning electron microscopy analyses. Thermal stability, hydrophilicity, swelling, mechanical, biodegradation, protein absorption properties, and drug delivery application of PAMU- and CS-based hydrogels were also investigated. The swelling performance of the hydrogels was studied in acidic, neutral, and alkaline media. Swelling results showed that the hydrogels have higher swelling capacity in acidic and alkaline media than neutral medium. Biodegradation experiments of the hydrogels were also studied via hydrolytic and enzymatic experiments. The drug release property of the hydrogel was carried out using 5-fluoro uracil (5-FU), and 5-FU release capacity of the hydrogels was found in the range from 40.10% to 58.40% after 3 days.
机译：在该研究中，已经制备了可生物降解的和抗菌聚（偶氮甲基氨基甲酸酯）（普氏氨酰氨基 - 氨基甲酸酯）（帕氨酰胺）的水凝胶用于受控药物递送应用。通过傅里叶变换 - 红外线和扫描电子显微镜分析进行水凝胶的结构和形态学特性。还研究了热稳定性，亲水性，溶胀，机械，生物降解，蛋白质吸收性能和蛋白质水凝胶的药物递送应用。在酸性，中性和碱性介质中研究了水凝胶的溶胀性能。膨胀结果表明，水凝胶在酸性和碱性介质中具有比中性介质更高的溶胀容量。还通过水解和酶实验研究了水凝胶的生物降解实验。使用5-氟尿嘧啶（5-FU）进行水凝胶的药物释放性能，3天后，水凝胶的5-FU释放能力在40.10％至5​​8.40％的范围内。

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