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首页> 外文期刊>Polymers for advanced technologies >Synthesis of multiresponsive beta-cyclodextrin nanocomposite through surface RAFT polymerization for controlled drug delivery
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Synthesis of multiresponsive beta-cyclodextrin nanocomposite through surface RAFT polymerization for controlled drug delivery

机译：通过表面筏聚合对多型β-环糊精纳米复合物的合成控制药物递送

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In this study, a unique magnetic, pH, and thermo-responsive hydrogel nanocomposite was synthesized via surface reversible addition fragmentation chain transfer (RAFT) copolymerization of acrylic acid (AA) and N-isopropyl acrylamide (NIPAM) in the presence of magnetic beta-cyclodextrin (beta-CD). The nanocomposite demonstrated a pH-responsiveness behavior at pHs 3 and 9. Moreover, swelling behaviors of nanocomposite were measured in solutions with various temperatures. Furthermore, the nanocomposites exhibited high swelling capacity by applying an external magnetic field because of the presence of Fe3O4 nanoparticles in the polymer structure. Besides, the doxorubicin (DOX) loading and releasing behaviors of the hydrogel nanocomposites were studied because of the stimuli-responsive properties of the synthesized carriers. The adsorption of DOX obeyed a pseudo-second-order model and fitted well to the Langmuir isotherm model with the maximum adsorption capacity uptake of 291 mg g(-1). In conclusion, the hydrogel nanocomposites were found to be as potential nanocarriers for use in controlled release applications.
机译：在该研究中，在磁性β的存在下，通过表面可逆添加丙烯酸（AA）和N-异丙基丙烯酰胺（NIPAM）通过表面可逆添加碎片链转移（筏）共聚合成了独特的磁性，pH和热响应水凝胶纳米复合材料环糊精（Beta-CD）。纳米复合材料在pH 3和9处显示了pH-响应性行为。此外，在具有各种温度的溶液中测量纳米复合材料的溶胀行为。此外，由于在聚合物结构中存在Fe 3 O 4纳米颗粒，纳米复合材料通过施加外部磁场而表现出高溶胀容量。此外，由于合成载体的刺激性能，研究了水凝胶纳米复合材料的多柔比蛋白（DOX）加载和释放行为。 DOX的吸附遵循了伪二阶模型，并符合Langmuir等温模型，最大吸附能力摄取为291mg g（-1）。总之，发现水凝胶纳米复合材料是用于控制释放应用的潜在纳米载体。

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