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Synthesis of inositol-based star polymers through low ppm ATRP methods

机译：通过低PPM ATRP方法合成肌醇基恒星聚合物

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The vitamin B-8-based macroinitiator with six 2-bromoisobutyric initiating sites was prepared for the first time by the transesterification reaction of meso-inositol with 2-bromoisobutyryl bromide. A series of six-armed (co)polymers, containing hydrophilic poly(di(ethylene glycol) methyl ether methacrylate) and amphiphilic poly(di(ethylene glycol) methyl ether methacrylate)-block-poly(methyl methacrylate) as the arms and meso-inositol as the core, were obtained by low ppm atom transfer radical polymerization (ATRP) methods, utilizing 30ppm of catalyst complex. Under Fe-0-mediated supplemental activators and reducing agents ATRP, Cu-0-mediated supplemental activators and reducing agents ATRP, Ag-0-mediated activators regenerated by electron transfer ATRP, and simplified electrochemically mediated ATRP conditions, polymerization proceeded on to high conversion while maintaining low dispersity (D=1.05-1.16) giving well-defined six-armed star (co)polymers. H-1 NMR spectral results confirm the formation of new star-shaped block (co)polymers. The absence of intermolecular coupling reactions during synthesis was confirmed by gel permeation chromatography analyses of the side chains of received star (co)polymers. These vitamin B-8-based star (co)polymers may find biomedical applications as thermo-sensitive drug delivery systems, biosensors, and tissue engineering solutions. Copyright (c) 2017 John Wiley & Sons, Ltd.
机译：基于维生素B-8基大型脱发剂，其具有六种溴异丁酸的引发位点首次通过具有2-溴异丁酰基溴的溶剂化反应制备。一系列六臂（CO）聚合物，含有亲水性聚（二（乙二醇）甲基醚甲基丙烯酸甲酯）和两亲硅（二（乙二醇）甲基醚甲基丙烯酸甲酯） - 伯克聚（甲基丙烯酸甲酯）作为臂和梅索 - 肌醇作为核心，通过低PPM原子转移自由基聚合（ATRP）方法获得，利用30ppm的催化剂复合物。在Fe-0-介导的补充活化剂和还原剂ATRP，Cu-0介导的补充活化剂和还原剂ATRP，Ag-0介导的Actizatientator通过电子转移收集，并简化电化学介导的ATRP条件，对高转化进行了高转化在保持低分散度（D = 1.05-16）的同时，提供明确定义的六臂（CO）聚合物。 H-1 NMR光谱结果证实了新星形块（CO）聚合物的形成。通过凝胶渗透色谱法分析所接受的星（共）聚合物的侧链的凝胶渗透色谱分析来证实合成中的分子间偶联反应。这些维生素B-8的明星（CO）聚合物可以发现生物医学应用作为热敏药物递送系统，生物传感器和组织工程解决方案。版权所有（c）2017 John Wiley＆Sons，Ltd。

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