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首页> 外文期刊>Polymers for advanced technologies >Hybrid cross‐linked hydrogels as a technology platform for inin vitrovitro release of cephradine
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Hybrid cross‐linked hydrogels as a technology platform for inin vitrovitro release of cephradine

机译：混合交联水凝胶作为技术平台 在中 体外体外 释放Cepharine.

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>Hydrogel‐based drug delivery systems can leverage therapeutically favorable upshots of drug release and found clinical uses. Hydrogels offer temporal and spatial control over the release of different therapeutic agents. Because of their tailor made controllable degradability, physical properties, and ability to prevent the labile drugs from degradation, hydrogels provide platform on which diverse physicochemical interactions with entrapped drugs cause to control drug release. Herein, we report the fabrication of novel vinyltrimethoxy silane (VTMS) cross‐linked chitosan/polyvinyl pyrrolidone hydrogels. Swelling in distilled water in conjunction with different buffer and electrolyte solutions was performed to assess the swellability of hydrogels. Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and X‐ray diffraction (XRD) analysis were further conducted to investigate the possible interactions between components, thermal stability, and crystallinity of as‐prepared hybrid hydrogels, respectively. In vitro time‐dependent biodegradability, antimicrobial study, and cytotoxicity were also carried out to evaluate their extensive biocompatibility and cytotoxic behavior. More interestingly, in vitro drug release study allowed for the controlled release of cephradine. Therefore, this facile strategy developed the novel biocompatible and biodegradable hybrid hydrogels, which could significantly expand the scope of these hydrogels in other biomedical applications like scaffolds, skin regeneration, tissue engineering, etc.
机译： >水凝胶基药物递送系统可以利用治疗性良好的药物释放截头并发现临床用途。水凝胶对不同治疗剂的释放提供时间和空间控制。由于其裁缝可控可降解性，物理性质和防止不稳定药物免于降解的能力，水凝胶提供了与捕集药物的不同物理化学相互作用导致药物释放的平台。在此，我们报告了新型乙烯基三氧基硅烷（VTMS）交联壳聚糖/聚乙烯吡咯烷酮水凝胶的制备。进行与不同的缓冲液和电解质溶液结合在蒸馏水中，以评估水凝胶的可溶胀性。进一步进行了傅里叶变换红外光谱（FTIR），热重分析（TGA）和X射线衍射（XRD）分析，以研究分别的组分，热稳定性和结晶性与制备的混合水凝胶之间的可能相互作用。还进行了体外时间依赖性生物降解性，抗微生物研究和细胞毒性，以评估其广泛的生物相容性和细胞毒性行为。更有趣的是，体外药物释放研究允许对Cepharine的控释释放。因此，这种容易策略开发了新型的生物相容性和可生物降解的杂交水凝胶，其可以显着扩展这些水凝胶在其他生物医学应用中的范围，如支架，皮肤再生，组织工程等。

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