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首页> 外文期刊>Plasmid: An International Journal Devoted to Extrachromosomal Gene Systems >Antibiotic resistance plasmids and mobile genetic elements of Clostridium perfringens
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Antibiotic resistance plasmids and mobile genetic elements of Clostridium perfringens

机译：Perfringens的抗生素抗性质粒和流动遗传元件

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摘要

Clostridium perfringensis an anaerobic bacterium that is a major human and animal pathogen. The key features ofC.perfringens-mediated infections are that disease pathogenesis involves the production of protein toxins and that disease epidemiology generally involves the production of environmentally resistant endospores. Many of the toxins involved in these diseases are encoded on conjugative plasmids that are closely related to the paradigm tetracycline resistance plasmid pCW3. This plasmid encodes the Tet(P) tetracycline resistance determinant, and thetcplocus, which mediates conjugative transfer and is also present on the toxin plasmids. In addition to being directly responsible for the widely dispersed distribution of the Tet(P) determinant, which is not located on a transposable genetic element, this family of conjugative plasmids facilitates the spread of other mobile resistance elements. These elements include the chloramphenicol resistance integrative mobilisable elements typified by Tn4451, the bacitracin resistance integrative conjugative element typified by ICECp1, and the lincomycin resistance transferable insertion sequence typified by tISCpe8. Each of these elements are found on conjugative plasmids that are closely related to pCW3, providing evidence that this large plasmid family has a key role in the distribution of antibiotic resistance genes inC.perfringens.
机译：Clostridium perfringensis是一种厌氧细菌，是一种主要的人和动物病原体。培养型介导的感染的关键特征是疾病发病机制涉及蛋白质毒素的产生，并且该疾病流行病学通常涉及产生无害环境抑制的内孢子。这些疾病中涉及的许多毒素是对与范式四环素抗性质粒PCW3密切相关的共轭质粒。该质粒编码TET（P）四环素抗性决定簇，介导缀合物转移并存在于毒素质粒上。除了直接负责不在可转换遗传元素的TET（P）的TET（P）决定簇的广泛分散的分布之外，该缀合质粒家族促进了其他移动阻力元素的扩散。这些元素包括氯霉素抗性可迁移的可迁移元素，其代表于TN4451，该抗链族素抗性整合结合元素，其代表于ICECP1，以及由TICPE8的型号键化的林霉素抗性可转移序列。这些元素中的每一个都存在于与PCW3密切相关的共轭质粒上，提供了这种大质粒家族在抗生素抗性基因Inc.perfringens的分布中具有关键作用。

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