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首页> 外文期刊>Platelets >Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals
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Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals

机译：在艾滋病毒阳性个体冠状动脉疾病的第一次诊断之前检测到血小板衍生的可溶性糖蛋白VI的水平降低

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摘要

HIV-positive patients are at increased risk for coronary artery disease (CAD); changes in platelet activation may play a role. This study was performed to determine if levels of soluble glycoprotein VI (sGPVI), a platelet-specific marker of activation, were different in HIV-positive patients compared with HIV-negative controls and further if levels were predictive of CAD in HIV. Twenty-four HIV-positive individuals (HIV cases) with CAD were compared with 46 age- and sex-matched HIV-positive controls without CAD and 41 HIV-negative controls (healthy controls). Platelet activation (represented by sGPVI level) was compared 12 months and 1 month prior to CAD diagnosis. sGPVI was quantified by ELISA. sGPVI levels were higher in HIV-positive subjects (combined) than healthy controls (122.5 ng/mL [interquartile ranges (IQR) 90.3-160.5] versus 84.7 ng/mL [IQR 48.6-119.5], p <0.001). Twelve months before the event, there was no difference in sGPVI between HIV cases and HIV controls (113.4 ng/mL [IQR 85.6-141.65] versus 128.0 ng/mL [IQR 96.6-179.4], p = 0.369). One month prior to the event, sGPVI was significantly lower in HIV cases compared with HIV controls (109.0 ng/mL [IQR 79.4-123.4] versus 133.9 ng/mL [IQR 112.7-171.9], p = 0.010). These results remained significant following adjustment for possible confounders. This work demonstrates that HIV infection is associated with higher sGPVI levels. A fall in sGPVI immediately prior to first coronary artery event may reflect a loss of negative-feedback mechanism and be an important pathological step in the development of symptomatic CAD, but further work is needed to confirm these findings and determine their clinical impact.
机译：艾滋病毒阳性患者处于冠状动脉疾病（CAD）的风险增加;血小板激活的变化可能发挥作用。进行该研究以确定可溶性糖蛋白VI（SGPVI）的水平，血清阳性患者的血小板特异性活化标记物不同，与HIV阴性对照相比，进一步的艾滋病毒中CAD的预测性。将24例HIV阳性个体（HIV病例）与CAD进行比较，而46岁和性别匹配的艾滋病毒阳性对照，没有CAD和41个HIV阴性对照（健康对照）。在CAD诊断前12个月和1个月比较血小板激活（由SGPVI水平表示）。 SGPVI通过ELISA量化。艾滋病毒阳性受试者（组合）的SGPVI水平高于健康对照（122.5ng / mL [四分位数范围（IQR）90.3-160.5]，而84.7 ng / ml [IQR 48.6-119.5]，P <0.001）。在事件前12个月，HIV病例和HIV控制之间的SGPVI没有差异（113.4 ng / ml [IQR 85.6-141.65]与128.0 ng / ml [IQR 96.6-179.4]，p = 0.369）。在事件前一个月，HIV病例中的SGPVI与HIV对照相比显着降低（109.0 ng / ml [IQR 79.4-123.4]与133.9 ng / ml [IQR 112.7-171.9]，P = 0.010）。这些结果在可能的混淆方面进行了重大调整。这项工作表明HIV感染与较高的SGPVI水平相关。在第一次冠状动脉事件之前，立即在SGPVI中跌落，可能反映了负反馈机制的丧失，并成为发育症状CAD的重要病理步骤，但需要进一步的工作来确认这些发现并确定其临床影响。

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