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首页> 外文期刊>Platelets >Clopidogrel use and smoking cessation result in lower coated-platelet levels after stroke
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Clopidogrel use and smoking cessation result in lower coated-platelet levels after stroke

机译：氯吡格雷使用和吸烟戒烟导致中风后涂层血小板水平降低

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Coated-platelets are a subset of highly procoagulant platelets elevated in patients with non-lacunar ischemic stroke and associated with stroke recurrence. Cross-sectional studies in controls have shown that smoking is associated with higher coated-platelet levels while chronic use of serotonin reuptake inhibitors (SSRIs), statins or aspirin is associated with lower coated-platelet levels. We now investigate if initiation of treatment with SSRIs, statins, clopidogrel, aspirin or oral anticoagulants and smoking cessation impacts coated-platelet levels at 90 days after ischemic stroke. Coated-platelet levels, reported as percent of cells converted to coated-platelets, were measured in 87 consecutive patients with stroke at baseline and repeated at 90 days. Repeated-measure ANOVA was used to determine if initiation of treatment with individual medications or smoking cessation impacted coated-platelet levels. Decreased coated-platelets levels at 90 days as compared to baseline were observed after initiation of treatment with clopidogrel (p = .0001, partial eta(2) = 0.17) and smoking cessation (p = .014, partial eta(2) = 0.10). Initiation of treatment with SSRIs, statins, aspirin or oral anticoagulants did not result in significant changes in coated-platelet potential. These novel longitudinal data suggest that clopidogrel therapy and smoking cessation attenuate coated-platelet potential at 90 days after ischemic stroke.
机译：涂层血小板是非血管疮缺血性卒中患者升高的高度探测剂血小板的子集，并且与中风复发相关。对照的横截面研究表明，吸烟与较高的涂层血小板水平相关，同时慢性使用血清素再摄取抑制剂（SSRIS），他汀类药物或阿司匹林与较低的血小板水平有关。我们现在调查SSRIS，他汀类药物，氯吡格雷，阿司匹林或口服抗凝剂和吸烟在缺血性卒中后90天内涂有血小板水平的调查。报告称为转化为涂层血小板的细胞百分比的涂层血小板水平在87例中，在基线的87例中卒中测量，并在90天内重复。反复测量Anova用于确定用各种药物或吸烟的治疗是否受到影响影响涂层血小板水平。在用氯吡格雷的处理开始后，观察到与基线相比的涂层血小板水平降低（P = .0001，部分ETA（2）= 0.17）和吸烟（P = .014，部分ETA（2）= 0.10 ）。用SSRIS，他汀类药物，阿司匹林或口服抗凝剂治疗的启动并未导致涂层血小板电位的显着变化。这些新型纵向数据表明，氯吡格雷治疗和吸烟停止在缺血性卒中后90天衰减涂层血小板电位。

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