• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Prion >As a toxin dies a prion comes to life: A tentative natural history of the [Het-s] prion
【24h】

As a toxin dies a prion comes to life: A tentative natural history of the [Het-s] prion

机译：由于毒素死亡，朊病毒来到生命：[het-s]朊病毒的暂定自然历史

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A variety of signaling pathways, in particular with roles in cell fate and host defense, operate by a prion-like mechanism consisting in the formation of open-ended oligomeric signaling complexes termed signalosomes. This mechanism emerges as a novel paradigm in signal transduction. Among the proteins forming such signaling complexes are the Nod-like receptors (NLR), involved in innate immunity. It now appears that the [Het-s] fungal prion derives from such a cell-fate defining signaling system controlled by a fungal NLR. What was once considered as an isolated oddity turns out to be related to a conserved and widespread signaling mechanism. Herein, we recall the relation of the [Het-s] prion to the signal transduction pathway controlled by the NWD2 Nod-like receptor, leading to activation of the HET-S pore-forming cell death execution protein. We explicit an evolutionary scenario in which formation of the [Het-s] prion is the result of an exaptation process or how a loss-of-function mutation in a pore-forming cell death execution protein (HET-S) has given birth to a functional prion ([Het-s]).
机译：特别是在细胞命运和宿主防御中具有统一的各种信号通路，通过朊病毒机构操作，该机构包括形成的开口未结束的低聚信号传递复合物称为信号弹素。这种机制出现为信号转导的新型范式。形成这种信号配合物的蛋白质是涉及先天免疫的NOD样受体（NLR）。现在似乎[HET-S]真菌朊病毒源于定义由真菌NLR控制的信号系统的这种细胞命运。一旦被认为是孤立的奇怪，曾经被认为是与保守和广泛的信号传导机制相关的。在此，我们回顾[HET-S]朊病毒对由NWD2 NOD样受体控制的信号转导途径的关系，导致HET-S孔形成细胞死亡执行蛋白的激活。我们明确了一种进化场景，其中[HET-S]朊病毒是展开过程的结果或孔形成细胞死亡执行蛋白（HET-S）中的功能突变如何生育功能朊病毒（[het-s]）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号