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Drug-induced cytokine release syndrome

机译:药物诱导的细胞因子释放综合征

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摘要

Cytokine release syndrome is a potentially fatal, intense systemic inflammatory reaction that can be caused by certain drugs, usually with administration of the first dose. The symptoms are nonspecific: fever, chills, hot flushes, alterations in heart rate and blood pressure, dyspnoea or chest tightness, abdominal or low back pain, nausea, vomiting or diarrhoea, rash, pruritus, etc. Patients sometimes develop life-threatening single or multiple organ failure. The syndrome diminishes in intensity with repeated administration of the drug responsible. This syndrome occurs when an unusually high number of immune cells become activated and release cytokines, which are inflammatory mediators. The symptoms are similar to those of an immune-mediated hypersensitivity reaction, but their mechanisms, consequences and outcomes differ.
机译:细胞因子释放综合征是一种潜在的致命,强烈的全身炎症反应,可能是由某些药物引起的,通常是给药第一剂量。 症状是非特异性:发烧,寒冷,热冲洗,心率和血压的改变,呼吸困难或胸部紧绷,腹部或腰痛,恶心,呕吐或腹泻,皮疹,瘙痒等患者有时会培养危及生命的单身 或多个器官失败。 综合征在于反复施用药物的强度减少。 当异常大量的免疫细胞被激活并释放细胞因子时,发生这种综合症,这是炎症介质。 症状与免疫介导的超敏反应的症状类似,但它们的机制,后果和结果不同。

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    《Prescrire international》 |2019年第208期|共3页
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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
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