oxycodone + naloxone (oxsynia0) in restless legs syndrome-Risk of addiction for only minor efficacy

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oxycodone + naloxone (oxsynia0) in restless legs syndrome-Risk of addiction for only minor efficacy

机译：羟氢酮+纳洛酮（牛津0）在焦躁的腿综合征 - 瘾的风险成瘾只是轻微的疗效

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In a randomised trial in 306 patients with very severe restless legs syndrome insufficiently relieved by various drugs, the fixed-dose combination oxycodone + naloxone, administered for 12 weeks, alleviated symptoms to a slightly greater degree than placebo (a difference of about 7 points on a scale of 0 to 40). Similar results were obtained in another trial that compared oxycodone alone versus placebo in 11 patients. Like all opioids, oxycodone has serious adverse effects, in particular a risk of addiction and potentially fatal overdose. As restless legs syndrome is a chronic condition, prolonged use of oxycodone + naloxone is a risk to take into account, making its harm-benefit balance uncertain in this situation.

机译：在306例随机试验中，在306例非常严重的躁动腿综合征中，通过各种药物不充分缓解，固定剂量组合羟考酮+纳洛酮施用12周，缓解症状比安慰剂略大（差异约7点比例为0到40）。在另一项试验中获得了类似的结果，其单独将羟考酮与11名患者中的安慰剂进行比较。与所有阿片类药物一样，羟考酮具有严重的不利影响，特别是成瘾的风险和潜在的致命过量。随着焦躁的腿综合征是一种慢性条件，长期使用羟考酮+纳洛酮是一种考虑的风险，在这种情况下造成危害效益平衡。

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《Prescrire international》 |2019年第205期|共3页
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正文语种 eng
中图分类药学;
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2. oxycodone + naloxone (oxsynia0) in restless legs syndrome-Risk of addiction for only minor efficacy [J] . Prescrire international . 2019,第205期

机译：羟氢酮+纳洛酮（牛津0）在焦躁的腿综合征 - 瘾的风险成瘾只是轻微的疗效
3. Intractable restless legs syndrome: role of prolonged-release oxycodone–naloxone [J] . Stefano de Biase, Mariarosaria Valente, Gian Luigi Gigli Neuropsychiatric Disease and Treatment . 2016,第1期

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4. Oxycodone/Naloxone PR: A Review in Severe Refractory Restless Legs Syndrome [J] . James E. Frampton1 CNS drugs . 2015,第6期

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5. Modeling Functional Processes of Brain Tissue: An fMRI Study on Patients with IM-Medicated Late-Onset Restless Leg Syndrome [C] . Amalia K. Ntemou, Evanthia E. Tripoliti, Persefoni N. Margariti Mediterranean Conference on Medical and Biological Engineering and Computing . 2020

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6. The Effectiveness of Aquatic Therapy on Sleep Quality and the Reduction of Restelss Legs Symptoms in an Individual with Restless Legs Syndrome [D] . Jeppson, Scott . 2019

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7. Sleep and Quality of Life Under Prolonged Release Oxycodone/Naloxone for Severe Restless Legs Syndrome: An Analysis of Secondary Efficacy Variables of a Double-Blind Randomized Placebo-Controlled Study with an Open-Label Extension [O] . Wolfgang H. Oertel, Yngve Hallström, Gerda M. Saletu-Zyhlarz, -1

机译：重度不安腿综合征的羟考酮/纳洛酮缓释下的睡眠和生活质量：双盲随机安慰剂对照研究与开放标签扩展的次要疗效变量分析
8. Sleep and Quality of Life Under Prolonged Release Oxycodone/Naloxone for Severe Restless Legs Syndrome: An Analysis of Secondary Efficacy Variables of a Double-Blind, Randomized, Placebo-Controlled Study with an Open-Label Extension [O] . Wolfgang H. Oertel, null null, Yngve Hallström, 2016

机译：严重不安定腿综合征的羟考酮/纳洛酮缓释下的睡眠和生活质量：双盲，随机，安慰剂对照研究与开放标签扩展的次要疗效变量分析

oxycodone + naloxone (oxsynia0) in restless legs syndrome-Risk of addiction for only minor efficacy

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