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首页> 外文期刊>Proceedings of the Institution of Mechanical Engineers, Part H. Journal of Engineering in Medicine >Flow resistance coefficient analysis of left anterior descending artery stenosis: A preliminary study
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Flow resistance coefficient analysis of left anterior descending artery stenosis: A preliminary study

机译：左前期下降动脉狭窄的流动性系数分析：初步研究

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As a non-invasive diagnosis method, computed tomographic angiography-based computational fluid dynamics is used to estimate fractional flow reserve of coronary arteries (FFRct). However, FFRct uses hypothetical hemodynamic flow conditions, and thus FFRct might cause mismatches (fractional flow reserve > 0.8) with invasive fractional flow reserve (<= 0.8). Additional computational fluid dynamics-based criteria are still needed to improve the accuracy of non-invasive diagnosis. In this article, a new concept of computed tomographic angiography-based flow resistance coefficient (FRCct) is proposed, and it tests pressure drops at coronary arteries under different blood flow rates and returns two constant flow resistance coefficients (A and B) for each artery. Specifically, 30 patients who were suspected to meet the treatment indication of their left anterior descending stenosis were tested with invasive fractional flow reserve and FRCct. The invasive fractional flow reserve divided the patients into a safe group (invasive fractional flow reserve > 0.8, 15 patients) and a sick group (invasive fractional flow reserve <= 0.8, 15 patients). A following FRCct indicated that the flow resistance coefficient always displayed a low value (A = 0.0039 +/- 2.7e-5; B = 0.079 +/- 0.0025) for the safe group, while the flow resistance coefficient always exhibited a high value (A = 0.0235 +/- 0.001; B = 0.270 +/- 0.108) for the sick group. The results of the statistical test indicated that the p-value was less than 0.05 for both A and B of the two groups. In conclusion, in addition to the FFRct, FRCct is a supplementary non-invasive method to evaluate the treatment indication of left anterior descending stenosis.
机译：作为非侵入性诊断方法，基于计算的基于血管造影的计算流体动力学用于估计冠状动脉（FFRCT）的分数流量储备。然而，FFRCT使用假设的血液动力流动条件，因此FFRCT可能导致侵入分数流量储备（<= 0.8）的不匹配（分数流量储备> 0.8）。仍然需要额外的计算流体动力学的标准来提高非侵入性诊断的准确性。在本文中，提出了一种基于计算的断层血管造影的流动性系数（FRCCT）的新概念，并且在不同血液流速下测试冠状动脉的压降，并为每个动脉返回两个恒定的流动性系数（A和B） 。具体而言，使用侵入性分数流量储备和FRCCT测试30名怀疑患者左侧前期下降狭窄的治疗表征的患者。侵入性分数流量储备将患者分为安全组（侵入分数流量储备> 0.8,15患者）和病态（侵入性分数流量储备<= 0.8,15患者）。以下FRCCT表示安全组的流动性系数总是显示出低值（a = 0.0039 +/- 2.7e-5; b = 0.079 +/- 0.0025），而流动性系数始终呈现高值（ SIGH组的A = 0.0235 +/- 0.001; b = 0.270 +/- 0.108）。统计测试的结果表明，两组的A和B的p值小于0.05。总之，除了FFRCT之外，FFRCT还为辅助非侵入性方法，用于评估左前期下降狭窄的治疗指示。

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