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首页> 外文期刊>Pregnancy hypertension >Diagnostic utility of angiogenic biomarkers in pregnant women with suspected preeclampsia: A health economics review
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Diagnostic utility of angiogenic biomarkers in pregnant women with suspected preeclampsia: A health economics review

机译：疑似孕妇血管生成生物标志物的诊断效用于疑似预防普利克斯妇女：卫生经济评论

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摘要

Preeclampsia is a major cause of morbidity and mortality, can be difficult to diagnose, and is associated with significant healthcare costs. The prediction, diagnosis and prognosis of preeclampsia have depended on repeated assessment of women with known risk factors, including intensive monitoring and hospitalization. Many of these women may never go on to develop preeclampsia. Recent developments in the pathogenesis of preeclampsia have shown that maternal serum biomarkers can be used to predict preeclampsia. When the ratio of the anti-angiogenic soluble fms-like tyrosine kinase-1 (sFlt-1) and the pro-angiogenic placental growth factor from the placenta is altered, preeclampsia becomes more likely, providing a diagnostic measurement for risk. The use of angiogenic biomarkers in addition to standard clinical tests can more accurately predict which women are at risk of developing preeclampsia and which are at low or moderate risk, which is likely to streamline the management of pregnant women and target resources in a more efficient way. The studies reviewed here all demonstrate cost savings from use of angiogenic biomarker tests as an addition to standard care.
机译：预口度是发病率和死亡率的主要原因，可能难以诊断，并与大量医疗保健成本有关。预先普利坦斯的预测，诊断和预后取决于对具有已知风险因素的妇女的重复评估，包括密集监测和住院。其中许多妇女可能永远不会继续开发出普莱克萨里帕西亚。最近先兆子痫发病机制的发展表明，母体血清生物标志物可用于预测预痫胰岛素。当改变抗血管生成可溶性FMS样酪氨酸激酶-1（SFLT-1）和胎盘的促血管生成胎盘生长因子的比例时，预口度变得更有可能，为风险提供诊断测量。除标准临床试验外，使用血管生成生物标志物可以更准确地预测哪些女性有哪些妇女患有预坦克敏的风险，并且处于低或中等风险，这可能以更有效的方式简化孕妇和目标资源的管理。这里审查的研究全部表现出使用血管生成生物标志物试验的成本节省，作为标准护理的补充。

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