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首页> 外文期刊>Progress in Artificial Intelligence >Physical Activity and the Development of Post-Transplant Diabetes Mellitus, and Cardiovascular- and All-Cause Mortality in Renal Transplant Recipients
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Physical Activity and the Development of Post-Transplant Diabetes Mellitus, and Cardiovascular- and All-Cause Mortality in Renal Transplant Recipients

机译：身体活动和移植后糖尿病的发育，肾移植受者的心血管和全导致死亡率

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(1) Background: Little is currently known about the health impacts of daily-life moderate-to-vigorous physical activity (MVPA) in relation to the development of post-transplant diabetes mellitus (PTDM) and the long-term survival of renal transplant recipients (RTRs). (2) Methods: We analyzed self-reported data on MVPA within non-occupational and occupational domains, estimated with the SQUASH questionnaire, from a prospective cohort study of RTRs (n = 650) with a functioning graft exceeding 1 year. PTDM diagnoses were based on plasma glucose levels (>= 126 mg/dL), HbA1c (>= 6.5%), and the use of antidiabetic medication. Mortality data were retrieved from patient files up to the end of September 2015. (3) Results: During a median follow-up period of 5.3 years, 50 patients (10%) developed PTDM and 129 (19.8%) died. Of these deaths, 53 (8.9%) were caused by cardiovascular disease. Cox regression analyses showed that higher MVPA levels among patients were associated with a lower risk of PTDM (hazard ratio (HR); 95% confidence interval (95%CI) = 0.49; 0.25-0.96, p = 0.04), cardiovascular- (0.34; 0.15-0.77, p = 0.01), and all-cause mortality (0.37; 0.24-0.58, p < 0.001) compared with No-MVPA patients, independently of age, sex, and kidney function parameters. Associations of MVPA with cardiovascular and all-cause mortality remained significant and materially unchanged following further adjustments made for transplant characteristics, lifestyle factors, metabolic parameters, medication use, and creatinine excretion (muscle mass). However, the association between MVPA and PTDM was no longer significant after we adjusted for metabolic confounders and glucose levels. (4) Conclusion: Higher MVPA levels are associated with long-term health outcomes in RTRs.
机译：（1）背景：目前关于日常生活中度至活力的身体活动（MVPA）的健康影响，与移植后糖尿病（PTDM）的发展以及肾移植的长期存活收件人（rtrs）。 （2）方法：从南瓜问卷估计的非职业和职业域内的自我报告数据分析了在非职业和职业领域内的自我报告数据，从RTR（n = 650）的潜在队列研究超过1年的运作嫁接。 PTDM诊断基于血浆葡萄糖水平（> = 126mg / dL），HBA1C（> = 6.5％），以及使用抗糖尿病药物。从患者文件中检索到2015年9月底的死亡率数据。（3）结果：在5.3岁的中间后续期间，50名患者（10％）发达的PTDM和129（19.8％）死亡。这些死亡中，53（8.9％）是由心血管疾病引起的。 Cox回归分析表明，患者中的较高的MVPA水平与较低的PTDM风险（危害比（HR）; 95％置信区间（95％CI）= 0.49; 0.25-0.96，P = 0.04），心血管 - （0.34 ; 0.15-0.77，p = 0.01），和所有原因死亡率（0.37; 0.24-0.58，p <0.001）与No-MVPA患者，独立于年龄，性别和肾功能参数相比。在移植特征，生活方式因素，代谢参数，药物用途和肌酐排泄（肌肉质量）的进一步调整之前，MVPA与心血管和全导致死亡的关联保持显着和物质不变。然而，在调整代谢混合物和葡萄糖水平后，MVPA和PTDM之间的关联不再重要。 （4）结论：较高的MVPA水平与RTR中的长期健康结果相关。

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