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Evaluation of Sperm Mitochondrial Function: A Key Organelle for Sperm Motility

机译：精子线粒体功能评价：精子运动的关键细胞器

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Introduction: The role of nutraceuticals in the treatment of male infertility, especially in the "idiopathic form", remains the subject of significant debate. Many antioxidants improve sperm motility but the exact mechanism by which they act is still unclear. Although several studies have shown a correlation between sperm motility and mitochondrial function, the effects of antioxidant therapy on mitochondrial membrane potential (MMP) are poorly studied. The first aim of this review was to evaluate the efficacy of antioxidants on mitochondrial function and, consequently, on sperm motility in male infertile patients. Material and Methods: we performed a systematic search of all randomized controlled and uncontrolled studies available in the literature that reported sperm motility and MMP at baseline and after antioxidant administration in-vivo and in-vitro in patients with idiopathic asthenozoospermia. Pubmed, MEDLINE, Cochrane, Academic One Files, Google Scholar and Scopus databases were used. Results: Unexpectedly, among 353 articles retrieved, only one study met our inclusion criteria and showed a significant effect of myoinositol on both MMP and sperm motility. We then summarized the main knowledge on anatomy and metabolism of sperm mitochondria, techniques allowing to assess sperm mitochondria function and its relationships with low sperm motility. Finally, we paid special attention to the effect of antioxidant/prokinetic molecules for the treatment of asthenozoospermia. Conclusions: This is the first systematic review that has attempted to evaluate the effects of antioxidants on MMP and sperm motility. Although results are not conclusive due to the dearth of studies, the close relationship between mitochondria and sperm motility is clear. The investigation of this correlation could provide valuable information to be exploited in clinical practice for the treatment of male infertility.
机译：介绍：营养素质在治疗男性不育症中的作用，特别是以“特发性形式”，仍然是重大辩论的主题。许多抗氧化剂改善了精子运动，但它们行为的确切机制仍然尚不清楚。虽然有几项研究表明了精子运动和线粒体功能之间的相关性，但抗氧化治疗对线粒体膜电位（MMP）的影响很差。本综述的首次目的是评估抗氧化剂对线粒体功能的疗效，从而对男性不孕患者的精子活力。材料和方法：我们对文献中报告的文献中可用的所有随机控制和不受控制的研究进行了系统搜索，该研究报告了患有特发性哮喘患者的体内和体外抗氧化剂给药后的精子运动和MMP。使用PubMed，Medline，Cochrane，学术一张文件，Google学者和Scopus数据库。结果：出乎意料地，在检索到353篇文章中，只有一项研究达到了我们的纳入标准，并显示了肌肌醇对MMP和精子运动的显着效果。然后，我们总结了对精子线粒体的解剖学和代谢的主要知识，允许评估精子线粒体功能及其与低精子运动的关系的技术。最后，我们特别注意抗氧化剂/动力分子治疗哮喘患者的影响。结论：这是第一次系统评价，试图评估抗氧化剂对MMP和精子运动的影响。虽然由于研究的缺乏结果，结果并不完全，但线粒体与精子运动之间的密切关系很清楚。对这种相关性的调查可以提供有价值的信息，以便在临床实践中被利用治疗男性不孕症。

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