• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Progress in Artificial Intelligence >A 28 Day Clinical Assessment of a Lactic Acid-containing Antimicrobial Intimate Gel Wash Formulation on Skin Tolerance and Impact on the Vulvar Microbiome
【24h】

A 28 Day Clinical Assessment of a Lactic Acid-containing Antimicrobial Intimate Gel Wash Formulation on Skin Tolerance and Impact on the Vulvar Microbiome

机译：对皮肤耐受性和对外阴微生物组的影响28天的临床评估含乳酸的抗微生物密集凝胶洗涤制剂

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

While intimate feminine hygiene products are widely used as part of daily cleansing routines, little is known about how these products impact the vulvovaginal area and its microbiome stability. This 4 week clinical study assessed tolerance of a novel gel wash containing lactic acid (pH 4.2) for external daily use when used on the external genital area and its effects on skin moisturization, vulvar skin pH, and the vulvar microbiome. After a 7 day pre-study conditioning period, 36 healthy females in three balanced age groups (18-29, 30-44, and 45-55 years) used the gel wash to cleanse their external genital area (mons pubis and vulva) and entire body at least once per day for 28 days. Skin tolerance of the gel wash was assessed by the gynecologist. Effects of the gel wash on vulvar skin microbiota were studied by performing bacterial 16S rRNA and fungal internal transcribed spacer (ITS) microbial richness and diversity analysis. Based on gynecologic assessment after 28 days of use, the gel wash showed acceptable tolerance, with no signs of increased dryness, redness, edema, itching, stinging, or burning. Use of the gel wash was associated with a significant increase in both short-term (single application) and longer-term (daily use for 28 days) skin moisturization. There was no significant change in vulvar skin pH over time with daily product use, and the gel wash did not significantly affect the natural vulvar microbiome species richness or diversity for bacteria or fungi. Results showed that this gel wash is a mild, moisturizing cleanser that maintains the natural pH and microbial diversity of vulvar skin. To our knowledge, this was the first study to assess the effect of an antimicrobial feminine gel wash on the natural pH and vulvar microbiome habitat of the skin using bacterial 16S rRNA and fungal ITS genetic sequencing techniques.
机译：虽然亲密的女性卫生产品被广泛用作日常清洁程序的一部分，但这些产品如何影响外阴阴压区域及其微生物组稳定性。这项4周的临床研究评估了含有乳酸（pH4.2）的新型凝胶洗涤剂（pH4.2）的耐受性，用于外部生殖器面积及其对皮肤保湿，外阴皮PH和外阴微生物的影响。经过7天的学习后调理期，三个平衡年龄组的36名健康女性（18-29,30-44和45-55岁）使用凝胶洗涤来清洁其外部生殖器面积（八娃娃和外阴）和整个身体至少每天一次28天。通过妇科医生评估凝胶洗涤的皮肤耐受性。通过进行细菌16SRRNA和真菌内转录的间隔（其）微生物丰富和分集分析，研究了凝胶洗涤对外阴皮肤微生物的影响。基于28天使用后的妇科评估，凝胶洗涤表现出可接受的耐受性，无需增加的干燥，发红，水肿，瘙痒，刺痛或燃烧。使用凝胶洗涤与短期（单一应用）和长期（每日使用28天）的显着增加有关。随着日期产品使用随着时间的推移，外阴皮肤pH没有显着变化，凝胶洗涤没有显着影响天然外阴微生物组种类的丰富或多样性的细菌或真菌。结果表明，这种凝胶洗涤是一种温和，保湿的洁面乳，可保持外阴皮肤的天然pH和微生物多样性。据我们所知，这是第一项评估抗菌女性凝胶洗涤对使用细菌16S rRNA和真菌其遗传测序技术对皮肤天然pH和外阴微生物血管栖息地的研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号