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首页> 外文期刊>Progress in Biophysics and Molecular Biology: An International Review Journal >Tale of tail current
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Tale of tail current

机译：尾部电流故事

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The largest biomass of channel proteins is located in unicellular organisms and bacteria that have no organs. However, orchestrated bidirectional ionic currents across the cell membrane via the channels are important for the functioning of organs of organisms, and equally concern both fauna or flora. Several ion channels are activated in the course of action potentials. One of the hallmarks of voltage-dependent channels is a 'tail current' - deactivation as observed after prior and sufficient activation predominantly at more depolarized potentials e.g. for Kv while upon hyperpolarization for HCN alpha subunits. Tail current also reflects the timing of channel closure that is initiated upon termination of stimuli. Finally, deactivation of currents during repolarization could be a selective estimate for given channel as in case of HERG, if dedicated long and more depolarized 'tail pulse' is used. Since from a holding potential of e.g. -70 mV are often a family of outward K+ currents comprising I-A and I-K are simultaneously activated in native cells. (C) 2019 Elsevier Ltd. All rights reserved.
机译：信道蛋白最大的生物量位于单细胞生物和没有器官的细菌中。然而，经由通道穿过细胞膜的策划双向离子电流对于生物体的器官的运作是重要的，并且同样涉及动物群或植物群。在动作电位的过程中激活了几个离子通道。电压依赖信道的一个标志之一是“尾电流” - 去激活，如先前的和足够的激活在更多的去极化电位下方。对于KV而在HCN alpha亚基的超极化时。尾电流还反映了在终止刺激后启动的通道闭合的定时。最后，在拒收期间的电流停用可能是给定通道的选择性估计，因为在HERG的情况下，如果使用专用的长而更偏振的“尾部脉冲”。由于从例如举起的潜力。 -70 mV通常是一种向外k +电流的家族，包括I-A和I-K在天然细胞中激活。 （c）2019年elestvier有限公司保留所有权利。

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