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首页> 外文期刊>Prostaglandins and Other Lipid Mediators >Inhibition of soluble epoxide hydrolase reduces portal pressure by protecting mesenteric artery myogenic responses in cirrhotic rats
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Inhibition of soluble epoxide hydrolase reduces portal pressure by protecting mesenteric artery myogenic responses in cirrhotic rats

机译：可溶性环氧化物水解酶通过保护肝硬化大鼠的肠系膜动脉肌原致抗应答降低了门骨压力

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摘要

Hyperdynamic circulation contributes to the progress of portal hypertension in liver cirrhosis. We investigated the effects of soluble epoxide hydrolase (sEH) inhibition on portal pressure and the myogenic response of mesenteric arteries isolated from cirrhotic rats using the sEH inhibitor t-TUCB (trans-4-{4-[3-(4-trifluoromethoxypheny1)-ureido]cyclohexyloxy}benzoic acid). Cirrhotic tissues had a higher ratio of epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs) following increased CYP2C11 expression, which may be a protective response. In comparison with controls, myogenic responses of mesenteric arteries from cirrhotic rats were attenuated at 80-140 mmHg, while inhibition of sEH partly reversed the impaired myogenic constriction at 100-140 mmHg and exhibited better feedback of vascular smooth muscle to pressure variation. Inhibition of sEH reduced portal pressure by decreasing endothelial synthesis of nitric oxide. An imbalance between EETs and nitric oxide may account for hyperdynamic circulation. sEH inhibitors may provide a novel approach for treating cirrhosis of the liver.
机译：超动脉循环有助于肝硬化的门静脉高血压进展。使用SEH抑制剂T-Tucb（Trans-4- {4- [3-（4-三氟甲氧基苯基） - - ureido]环己氧基}苯甲酸）。在增加的CYP2C11表达增加后，肝脏组织与二羟基己二烯酸（DHET）具有更高的二羟基己二烯酸（DHET），这可能是一种保护反应。与对照相比，肝硬化大鼠中肠系膜动脉的肌原致反应在80-140mmHg中衰减，而SEH的抑制部分在100-140mmHg以100-140mmHg逆转过受损的肌菌收缩，并表现出更好地反馈血管平滑肌对压力变化。通过降低一氧化氮的内皮合成，抑制SEH降低的栅格压力。 EET和一氧化氮之间的不平衡可能考虑超动态循环。 SEH抑制剂可以提供一种治疗肝硬化的新方法。

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  • 作者

    Huang Yijun; Qin Jun; Sun Dong; Jiang Houli; Zheng Lei; He Yue; Gui Liang; Qian Binbin; Zhang Chihao; Luo Meng;

  • 作者单位

    Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Dept Gen Surg Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Renji Hosp Dept GI Surg Shanghai Peoples R China;

    New York Med Coll Dept Physiol Valhalla NY 10595 USA;

    New York Med Coll Dept Pharmacol Valhalla NY 10595 USA;

    Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Dept Gen Surg Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Dept Gen Surg Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Dept Gen Surg Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Dept Gen Surg Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Dept Gen Surg Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Dept Gen Surg Shanghai Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    Portal hypertension; Soluble epoxide hydrolase; Myogenic response; Epoxyeicosatrienoic acids; Liver cirrhosis;

    机译：门静脉高血压;可溶性环氧化物水解酶;肌原素反应;环氧酸二酸三烯酸;肝硬化;

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