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A preliminary study of cortical morphology in schizophrenia patients with a history of violence

机译：精神分裂症患者皮质形态的初步研究

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摘要

Clinical studies of patients with schizophrenia and a history of violence are challenging both from an ethical and practical perspective, and the neurobiological underpinnings remain largely unknown. We here present a comprehensive account of the brain cortical characteristics associated with violence in schizophrenia. We obtained 3T MRI scans and thorough clinical characterization of schizophrenia patients with a history of violence (murder, attempted murder, criminal assault, SCZ-V, n = 11), schizophrenia patients with no history of violence (SCZ-NV, n = 17), and healthy controls (HC, n = 19). Cortical thickness, area, and folding were analyzed vertex-wise across the cortical mantle (FreeSurfer). SCZ-V had significantly increased cortical folding in the visual and orbitofrontal cortex, and reduced cortical thickness within the precentral-, parietal-, temporal-, and fusiform cortex compared to SCZ-NV, as well as widespread regional thinning and increased folding compared to HC. There were no group differences in cortical area. A major limitation is the small subject sample. If replicated, the results from this pilot study suggest cortical abnormalities in areas involved in sensory processing, emotion recognition, and reward to be of importance to the neurobiology of violence in schizophrenia.
机译：来自精神分裂症患者的临床研究和暴力史来自伦理和实践的角度，既挑战，神经生物学的内衬仍然很大程度上未知。我们在这里全面叙述了与精神分裂症中的暴力相关的脑皮质特征。我们获得了3T MRI扫描和精神分裂症患者的彻底临床表征，暴力史（谋杀，企图谋杀，犯罪攻击，SCZ-V，N = 11），精神分裂症患者没有暴力史（SCZ-NV，N = 17 ）和健康对照（HC，N = 19）。皮质厚度，面积和折叠在皮质罩（FreeSurfer）上分析顶点。 SCZ-V在视觉和眶内皮质皮层中显着增加了皮质折叠，并与SCZ-NV相比，先前术，颞型，颞叶和梭形皮质中的皮质厚度降低，以及与HC。皮质区域没有组差异。一个主要限制是小主题样本。如果复制，这项试点研究的结果表明，参与感官加工，情感识别和奖励的地区的皮质异常对精神分裂症中暴力的神经生物学的重要性。

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